Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 2003611..2004356 Replicon chromosome
Accession NZ_CP062824
Organism Escherichia coli O167:H26 strain Res13-Lact-PER13-34

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag IMQ31_RS09625 Protein ID WP_161398213.1
Coordinates 2003611..2003979 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IMQ31_RS09630 Protein ID WP_024273779.1
Coordinates 2004000..2004356 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ31_RS09600 1999327..2000385 - 1059 WP_122987197.1 alpha/beta hydrolase -
IMQ31_RS09605 2000650..2001534 + 885 WP_001119037.1 LysR family transcriptional regulator -
IMQ31_RS09610 2002234..2002512 - 279 WP_072648672.1 hypothetical protein -
IMQ31_RS09615 2002680..2003231 - 552 Protein_1885 SDR family oxidoreductase -
IMQ31_RS09620 2003244..2003402 + 159 Protein_1886 integrase -
IMQ31_RS09625 2003611..2003979 - 369 WP_161398213.1 TA system toxin CbtA family protein Toxin
IMQ31_RS09630 2004000..2004356 - 357 WP_024273779.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IMQ31_RS09635 2004382..2004603 - 222 WP_161398214.1 DUF987 family protein -
IMQ31_RS09640 2004600..2005142 - 543 WP_161398215.1 DNA repair protein RadC -
IMQ31_RS09645 2005155..2005598 - 444 WP_161398216.1 antirestriction protein -
IMQ31_RS09650 2005629..2006450 - 822 WP_161398217.1 DUF945 domain-containing protein -
IMQ31_RS09655 2006571..2007035 - 465 WP_161398218.1 hypothetical protein -
IMQ31_RS09660 2007061..2007534 - 474 WP_161398219.1 hypothetical protein -
IMQ31_RS09665 2007555..2008244 - 690 WP_161398220.1 transcriptional regulator -
IMQ31_RS09670 2008459..2009334 - 876 WP_195714947.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE 1955429..2039697 84268


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13667.91 Da        Isoelectric Point: 8.7174

>T176722 WP_161398213.1 NZ_CP062824:c2003979-2003611 [Escherichia coli O167:H26]
MKNPPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSPVQAPYLTTTDILQARKACGLMSRCSYREVSNIVLSRSRL

Download         Length: 369 bp

>T176722 NZ_CP082916:2465583-2466068 [Salmonella enterica subsp. enterica serovar Newlands]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13082.68 Da        Isoelectric Point: 5.8720

>AT176722 WP_024273779.1 NZ_CP062824:c2004356-2004000 [Escherichia coli O167:H26]
MNNHSESGDKPENPACQQWGLKSTITPCFGARLVQEGNRVHFLADRAGFNGAFSDDDALHLDQVFPLILKQLELMLTSGE
LSSRHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPTQR

Download         Length: 357 bp

>AT176722 NZ_CP082916:2465308-2465595 [Salmonella enterica subsp. enterica serovar Newlands]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References