Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4170352..4170937 Replicon chromosome
Accession NZ_CP062821
Organism Providencia rettgeri strain Res13-Sevr-LER2-35

Toxin (Protein)


Gene name relE Uniprot ID D4C3N9
Locus tag IMQ36_RS19370 Protein ID WP_004905874.1
Coordinates 4170352..4170669 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4C3P0
Locus tag IMQ36_RS19375 Protein ID WP_004905876.1
Coordinates 4170650..4170937 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMQ36_RS19340 4166057..4166308 - 252 WP_102138194.1 DUF1471 domain-containing protein -
IMQ36_RS19345 4166578..4166916 + 339 WP_102138195.1 GIY-YIG nuclease family protein -
IMQ36_RS19350 4166889..4167392 - 504 WP_102138196.1 N-acetyltransferase -
IMQ36_RS19355 4167386..4167910 - 525 WP_195697859.1 SCP2 domain-containing protein -
IMQ36_RS19360 4168424..4169419 + 996 WP_102138198.1 U32 family peptidase -
IMQ36_RS19365 4169437..4170312 + 876 WP_102138199.1 U32 family peptidase -
IMQ36_RS19370 4170352..4170669 - 318 WP_004905874.1 type II toxin-antitoxin system YafQ family toxin Toxin
IMQ36_RS19375 4170650..4170937 - 288 WP_004905876.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IMQ36_RS19380 4171068..4172222 - 1155 WP_102138201.1 ABC transporter permease -
IMQ36_RS19385 4172222..4173367 - 1146 WP_102138202.1 ABC transporter permease -
IMQ36_RS19390 4173379..4174350 - 972 WP_102138203.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(14-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.96 Da        Isoelectric Point: 9.7799

>T176707 WP_004905874.1 NZ_CP062821:c4170669-4170352 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKKSWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Download         Length: 318 bp

>T176707 NZ_CP082909:5178173-5178463 [Endozoicomonas sp. 4G]
ATGACTGAACCCGTATACACTTATGACCCCGCTGCGGCACTGGACAGCCCGGAAGCCCGGGAGGTGTTTATTGCTGATGC
TTTTGAGACTGGCGACGCTTCTTATATTGCTAAGGCGCTGGGAGTTGTTGCCCGGGCTGAGGGGATGAGCAATATTGCCA
GACAAACCGGACTTTCCCGAGAGCAACTGTATCGCTCATTCAGCGAAGATGGAAACCCAACACTGAAGACCATCTTGAAT
GTCATGAAGGCCTTGGGCTTTACCATCACCGCTACTAAAAATCTAACATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10763.44 Da        Isoelectric Point: 5.8809

>AT176707 WP_004905876.1 NZ_CP062821:c4170937-4170650 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Download         Length: 288 bp

>AT176707 NZ_CP082909:5177875-5178180 [Endozoicomonas sp. 4G]
ATGATCACCATTAAAGAAACTGAGACCTACCGTAAGTGGGAGCGAAAGCTGAAGAATGCCCGGGCAAAAGCCATAATAGC
GGCCCGAGTATTTCGCTTGGCTAATGGCCTTCCTGGTGATGTTGCTCCGGTTGGCCAAGGGATCAGCGAACTTAGGGTTC
ATTACGGACCTGGATACCGGGTGTACTTTCGCCAACAAGGGAACGAAATCATTCTTTTGTTGTGTGGAGGGGACAAGAGT
ACTCAGAGCAAAGATATAGAGCTTGCTAAACAGCTGGCACAAGAATGGAGGAAAAGTGATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D4C3N9

Antitoxin

Source ID Structure
AlphaFold DB A0A345M0A6

References