Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 652614..653103 Replicon chromosome
Accession NZ_CP062788
Organism Aestuariispira ectoiniformans strain SWCN16

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IF205_RS03235 Protein ID WP_259781858.1
Coordinates 652810..653103 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IF205_RS03230 Protein ID WP_259781857.1
Coordinates 652614..652820 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF205_RS03195 647751..648119 + 369 WP_259781851.1 histidine triad nucleotide-binding protein -
IF205_RS03200 648126..648614 + 489 WP_259781852.1 GNAT family N-acetyltransferase -
IF205_RS03205 649274..649591 + 318 WP_259781853.1 hypothetical protein -
IF205_RS03210 649708..649866 - 159 WP_259781854.1 hypothetical protein -
IF205_RS03215 649975..650178 - 204 WP_259781855.1 hypothetical protein -
IF205_RS03220 650343..651563 - 1221 WP_259781856.1 MFS transporter -
IF205_RS03225 651662..652462 + 801 WP_259783227.1 helix-turn-helix transcriptional regulator -
IF205_RS03230 652614..652820 + 207 WP_259781857.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF205_RS03235 652810..653103 + 294 WP_259781858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IF205_RS03240 653128..653421 - 294 WP_259781859.1 ferritin-like domain-containing protein -
IF205_RS03245 653555..654175 - 621 WP_259781860.1 nucleotide exchange factor GrpE -
IF205_RS03250 654190..655230 - 1041 WP_259781861.1 heat-inducible transcriptional repressor HrcA -
IF205_RS03255 655409..656068 - 660 WP_259781862.1 glutathione S-transferase family protein -
IF205_RS03260 656164..656676 + 513 WP_259781863.1 helix-turn-helix domain-containing protein -
IF205_RS03265 656810..657523 + 714 WP_259781864.1 ribonuclease PH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-61)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11288.18 Da        Isoelectric Point: 10.9683

>T176601 WP_259781858.1 NZ_CP062788:652810-653103 [Aestuariispira ectoiniformans]
MTYKLEFNKSALKEWSKLEATTKAQFKKKLAERLEHPEVPASRLRMSDNAYKIKLRNSGYRLVYTVDNDRIVVTVVAVGK
RNRNVVYKAAKTRLKNT

Download         Length: 294 bp

>T176601 NZ_CP082840:2037741-2037843 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7656.63 Da        Isoelectric Point: 3.8627

>AT176601 WP_259781857.1 NZ_CP062788:652614-652820 [Aestuariispira ectoiniformans]
MTDLRRDPTPVVEAGQPVAVLNRNKPVSYMVPADIYEAMLDALEDIDDLKLVRERADEETVEVSLDDL

Download         Length: 207 bp

>AT176601 NZ_CP082840:c2037850-2037705 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References