Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3551360..3551838 Replicon chromosome
Accession NZ_CP062778
Organism Escherichia coli O157:H7 strain Z1836

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ64_RS18255 Protein ID WP_001303876.1
Coordinates 3551551..3551838 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ64_RS18250 Protein ID WP_000536233.1
Coordinates 3551360..3551551 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ64_RS18215 3546746..3547516 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ64_RS18220 3547538..3548284 - 747 WP_000788751.1 ATP-binding protein -
ILQ64_RS18225 3548291..3549400 - 1110 WP_021499850.1 putative primosomal protein I -
ILQ64_RS18230 3549479..3549934 + 456 WP_000273724.1 hypothetical protein -
ILQ64_RS18235 3550141..3550566 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ64_RS18240 3550550..3550822 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ64_RS18245 3550931..3551332 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ64_RS18250 3551360..3551551 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ64_RS18255 3551551..3551838 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ64_RS18260 3552116..3552271 + 156 WP_000379575.1 DUF1391 family protein -
ILQ64_RS18265 3552413..3552802 + 390 WP_000394511.1 hypothetical protein -
ILQ64_RS18270 3552989..3553174 - 186 WP_001133046.1 hypothetical protein -
ILQ64_RS18275 3553748..3553936 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ64_RS18280 3553933..3554124 + 192 WP_001098307.1 DUF1482 family protein -
ILQ64_RS18285 3554218..3556689 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176514 WP_001303876.1 NZ_CP062778:3551551-3551838 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176514 NZ_CP082827:c2630468-2630292 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176514 WP_000536233.1 NZ_CP062778:3551360-3551551 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176514 NZ_CP082827:c2630246-2629830 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References