Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4514064..4514603 Replicon chromosome
Accession NZ_CP062771
Organism Escherichia coli O157:H7 strain Z570

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag ILQ32_RS22855 Protein ID WP_001303998.1
Coordinates 4514343..4514603 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag ILQ32_RS22850 Protein ID WP_000729705.1
Coordinates 4514064..4514324 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ32_RS22830 4509818..4510603 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
ILQ32_RS22835 4510575..4512287 + 1713 Protein_4471 flagellar biosynthesis protein FlhA -
ILQ32_RS22840 4512432..4512929 - 498 Protein_4472 REP-associated tyrosine transposase RayT -
ILQ32_RS22845 4513105..4513878 - 774 WP_000543891.1 C40 family peptidase -
ILQ32_RS22850 4514064..4514324 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ILQ32_RS22855 4514343..4514603 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ILQ32_RS22860 4514759..4515499 + 741 WP_001225679.1 murein L,D-transpeptidase -
ILQ32_RS22865 4515470..4516237 - 768 WP_001301698.1 class II glutamine amidotransferase -
ILQ32_RS22870 4516342..4516920 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T176441 WP_001303998.1 NZ_CP062771:4514343-4514603 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T176441 NZ_CP082815:c2293084-2292980 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT176441 WP_000729705.1 NZ_CP062771:4514064-4514324 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT176441 NZ_CP082815:2292887-2292925 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References