Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3381136..3381931 | Replicon | chromosome |
| Accession | NZ_CP062763 | ||
| Organism | Escherichia coli O157:H7 strain Z885 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B7UP43 |
| Locus tag | ILQ36_RS17380 | Protein ID | WP_000854914.1 |
| Coordinates | 3381136..3381510 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0B0VS41 |
| Locus tag | ILQ36_RS17385 | Protein ID | WP_001280954.1 |
| Coordinates | 3381557..3381931 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ILQ36_RS17340 | 3376140..3376631 | - | 492 | WP_001301587.1 | DUF1097 domain-containing protein | - |
| ILQ36_RS17345 | 3376733..3377287 | - | 555 | WP_001001917.1 | molecular chaperone YcdY | - |
| ILQ36_RS17350 | 3377311..3378048 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| ILQ36_RS17355 | 3378103..3379041 | - | 939 | WP_000351284.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| ILQ36_RS17365 | 3379512..3380354 | - | 843 | WP_001280481.1 | DUF4942 domain-containing protein | - |
| ILQ36_RS17370 | 3380439..3380636 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| ILQ36_RS17375 | 3380648..3381139 | - | 492 | WP_000976853.1 | hypothetical protein | - |
| ILQ36_RS17380 | 3381136..3381510 | - | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
| ILQ36_RS17385 | 3381557..3381931 | - | 375 | WP_001280954.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ILQ36_RS17390 | 3382094..3382315 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| ILQ36_RS17395 | 3382378..3382854 | - | 477 | WP_001186738.1 | RadC family protein | - |
| ILQ36_RS17400 | 3382870..3383355 | - | 486 | WP_000214398.1 | antirestriction protein | - |
| ILQ36_RS17405 | 3383446..3384264 | - | 819 | WP_001234682.1 | DUF945 domain-containing protein | - |
| ILQ36_RS17410 | 3384604..3385674 | - | 1071 | WP_000102669.1 | patatin-like phospholipase family protein | - |
| ILQ36_RS17415 | 3385671..3386576 | - | 906 | WP_000203541.1 | chemotaxis protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | csgA / csgB / csgD / csgE / csgF / csgG | 3372023..3383355 | 11332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T176331 WP_000854914.1 NZ_CP062763:c3381510-3381136 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T176331 NZ_CP082780:40974-41324 [Bacillus aquiflavi]
TTGAATATCAAACGTGGAGACGTTTATTTTGCAGACCTATCCCCTGTTGTTGGTTCAGAACAAGGCGGTGTTCGGCCTGT
GCTTGTCATTCAAAACGACATTGGGAATCGGTTTAGTCCCACAGTAATTATTGCAGCCATAACTGCTCAAATCCAAAAAG
CAAAGCTGCCTACTCATGTTGAAATTGACGCGAAGCGTTACGGTTTTGAACGGGATTCGGTCATTTTATTAGAGCAAATT
CGTACAATTGATAAACAACGCTTAACCGATAAGATTACACATCTTGATGATGAAATGATGGAGAAAGTTGATGAAGCATT
ACAAGTTAGTTTAGGTCTCATCGAGTTTTAA
TTGAATATCAAACGTGGAGACGTTTATTTTGCAGACCTATCCCCTGTTGTTGGTTCAGAACAAGGCGGTGTTCGGCCTGT
GCTTGTCATTCAAAACGACATTGGGAATCGGTTTAGTCCCACAGTAATTATTGCAGCCATAACTGCTCAAATCCAAAAAG
CAAAGCTGCCTACTCATGTTGAAATTGACGCGAAGCGTTACGGTTTTGAACGGGATTCGGTCATTTTATTAGAGCAAATT
CGTACAATTGATAAACAACGCTTAACCGATAAGATTACACATCTTGATGATGAAATGATGGAGAAAGTTGATGAAGCATT
ACAAGTTAGTTTAGGTCTCATCGAGTTTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13718.51 Da Isoelectric Point: 6.6249
>AT176331 WP_001280954.1 NZ_CP062763:c3381931-3381557 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT176331 NZ_CP082780:40685-40969 [Bacillus aquiflavi]
GTGTCTGAATCCAGCACAGCAACAACAGAGATTTTAGTAAAACTACCGCAACATCTGTTATCTGAATTGGACGGTTATGT
TAAACAAGAAAATGGGAATCGCAGTGACTTTATTTATCAGGCAACAAAAATGTATTTGCGTGAAAGAAAAAAGAGACAAA
TTCGCGAAGCCATGAGAAGAGGCTATATGGAAATGGCAAAGATCAATTTAACGATTGCTTCGGAAGCATTTCAGGCAGAA
TACGAGGCAGAACATACAGTTGAACGTCTAGTAAGCGGAGGGTAA
GTGTCTGAATCCAGCACAGCAACAACAGAGATTTTAGTAAAACTACCGCAACATCTGTTATCTGAATTGGACGGTTATGT
TAAACAAGAAAATGGGAATCGCAGTGACTTTATTTATCAGGCAACAAAAATGTATTTGCGTGAAAGAAAAAAGAGACAAA
TTCGCGAAGCCATGAGAAGAGGCTATATGGAAATGGCAAAGATCAATTTAACGATTGCTTCGGAAGCATTTCAGGCAGAA
TACGAGGCAGAACATACAGTTGAACGTCTAGTAAGCGGAGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LXR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B0VS41 |