Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3592772..3593250 Replicon chromosome
Accession NZ_CP062755
Organism Escherichia coli O157:H7 strain Z903

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ39_RS18480 Protein ID WP_001303876.1
Coordinates 3592963..3593250 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ39_RS18475 Protein ID WP_000536233.1
Coordinates 3592772..3592963 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ39_RS18440 3588176..3588946 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ39_RS18445 3588968..3589714 - 747 WP_000788751.1 ATP-binding protein -
ILQ39_RS18450 3589721..3590812 - 1092 WP_001205823.1 hypothetical protein -
ILQ39_RS18455 3590891..3591346 + 456 WP_000273724.1 hypothetical protein -
ILQ39_RS18460 3591553..3591978 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ39_RS18465 3591962..3592234 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ39_RS18470 3592343..3592744 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ39_RS18475 3592772..3592963 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ39_RS18480 3592963..3593250 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ39_RS18485 3593528..3593683 + 156 WP_000379575.1 DUF1391 family protein -
ILQ39_RS18490 3593825..3594214 + 390 WP_000394511.1 hypothetical protein -
ILQ39_RS18495 3594401..3594586 - 186 WP_001133046.1 hypothetical protein -
ILQ39_RS18500 3595160..3595348 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ39_RS18505 3595345..3595536 + 192 WP_001098307.1 DUF1482 family protein -
ILQ39_RS18510 3595630..3598101 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T176222 WP_001303876.1 NZ_CP062755:3592963-3593250 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T176222 NZ_CP082772:c3201648-3201397 [Escherichia coli O2:H1]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT176222 WP_000536233.1 NZ_CP062755:3592772-3592963 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT176222 NZ_CP082772:c3201400-3201146 [Escherichia coli O2:H1]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References