Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3369611..3370406 Replicon chromosome
Accession NZ_CP062752
Organism Escherichia coli O157:H7 strain Z910

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ40_RS17315 Protein ID WP_000854914.1
Coordinates 3369611..3369985 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ40_RS17320 Protein ID WP_001280954.1
Coordinates 3370032..3370406 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ40_RS17275 3364615..3365106 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ40_RS17280 3365208..3365762 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ40_RS17285 3365786..3366523 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ40_RS17290 3366578..3367516 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ40_RS17300 3367987..3368829 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ40_RS17305 3368914..3369111 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ40_RS17310 3369123..3369614 - 492 WP_000976853.1 hypothetical protein -
ILQ40_RS17315 3369611..3369985 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ40_RS17320 3370032..3370406 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ40_RS17325 3370569..3370790 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ40_RS17330 3370853..3371329 - 477 WP_001186738.1 RadC family protein -
ILQ40_RS17335 3371345..3371830 - 486 WP_000214398.1 antirestriction protein -
ILQ40_RS17340 3371921..3372739 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ40_RS17345 3373079..3374149 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ40_RS17350 3374146..3375051 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgB / csgD / csgE / csgF / csgG 3360997..3371830 10833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T176183 WP_000854914.1 NZ_CP062752:c3369985-3369611 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T176183 NZ_CP082766:40344-40655 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT176183 WP_001280954.1 NZ_CP062752:c3370406-3370032 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT176183 NZ_CP082766:40652-41071 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References