Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3756267..3756972 Replicon chromosome
Accession NZ_CP062749
Organism Escherichia coli O157:H7 strain Z1486

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag ILQ41_RS19200 Protein ID WP_000539519.1
Coordinates 3756267..3756653 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ILQ41_RS19205 Protein ID WP_001280945.1
Coordinates 3756643..3756972 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ41_RS19180 3752271..3752897 + 627 WP_001295292.1 glutathione S-transferase GstB -
ILQ41_RS19185 3752894..3754009 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
ILQ41_RS19190 3754120..3754503 - 384 WP_000497137.1 biofilm formation regulator BssR -
ILQ41_RS19195 3754716..3756041 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
ILQ41_RS19200 3756267..3756653 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ41_RS19205 3756643..3756972 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
ILQ41_RS19210 3757042..3758370 - 1329 WP_000086905.1 GGDEF domain-containing protein -
ILQ41_RS19215 3758378..3760726 - 2349 WP_000950320.1 EAL domain-containing protein -
ILQ41_RS19220 3760904..3761815 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T176151 WP_000539519.1 NZ_CP062749:3756267-3756653 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T176151 NZ_CP082755:132780-132929 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT176151 WP_001280945.1 NZ_CP062749:3756643-3756972 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT176151 NZ_CP082755:c132735-132676 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References