Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3580172..3580967 Replicon chromosome
Accession NZ_CP062739
Organism Escherichia coli O157:H7 strain Z1723

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ILQ45_RS18540 Protein ID WP_000854914.1
Coordinates 3580172..3580546 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ILQ45_RS18545 Protein ID WP_001280954.1
Coordinates 3580593..3580967 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ45_RS18500 3575176..3575667 - 492 WP_001301587.1 DUF1097 domain-containing protein -
ILQ45_RS18505 3575769..3576323 - 555 WP_001001917.1 molecular chaperone YcdY -
ILQ45_RS18510 3576347..3577084 - 738 WP_000283664.1 zinc-binding phosphatase -
ILQ45_RS18515 3577139..3578077 - 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
ILQ45_RS18525 3578548..3579390 - 843 WP_001280481.1 DUF4942 domain-containing protein -
ILQ45_RS18530 3579475..3579672 - 198 WP_000839282.1 DUF957 domain-containing protein -
ILQ45_RS18535 3579684..3580175 - 492 WP_000976853.1 hypothetical protein -
ILQ45_RS18540 3580172..3580546 - 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ILQ45_RS18545 3580593..3580967 - 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ILQ45_RS18550 3581130..3581351 - 222 WP_001220314.1 DUF987 domain-containing protein -
ILQ45_RS18555 3581414..3581890 - 477 WP_001186738.1 RadC family protein -
ILQ45_RS18560 3581906..3582391 - 486 WP_000214398.1 antirestriction protein -
ILQ45_RS18565 3582482..3583300 - 819 WP_001234682.1 DUF945 domain-containing protein -
ILQ45_RS18570 3583640..3584710 - 1071 WP_000102669.1 patatin-like phospholipase family protein -
ILQ45_RS18575 3584707..3585612 - 906 WP_000203541.1 chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgD / csgE / csgF / csgG 3572767..3582391 9624


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T175999 WP_000854914.1 NZ_CP062739:c3580546-3580172 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T175999 NZ_CP082327:641712-642026 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT175999 WP_001280954.1 NZ_CP062739:c3580967-3580593 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT175999 NZ_CP082327:642023-642439 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References