Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3666807..3667285 Replicon chromosome
Accession NZ_CP062725
Organism Escherichia coli O157:H7 strain Z1813

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ52_RS19020 Protein ID WP_001303876.1
Coordinates 3666998..3667285 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ52_RS19015 Protein ID WP_000536233.1
Coordinates 3666807..3666998 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ52_RS18980 3662211..3662981 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ52_RS18985 3663003..3663749 - 747 WP_000788751.1 ATP-binding protein -
ILQ52_RS18990 3663756..3664847 - 1092 WP_001205823.1 hypothetical protein -
ILQ52_RS18995 3664926..3665381 + 456 WP_000273724.1 hypothetical protein -
ILQ52_RS19000 3665588..3666013 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ52_RS19005 3665997..3666269 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ52_RS19010 3666378..3666779 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ52_RS19015 3666807..3666998 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ52_RS19020 3666998..3667285 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ52_RS19025 3667563..3667718 + 156 WP_000379575.1 DUF1391 family protein -
ILQ52_RS19030 3667860..3668249 + 390 WP_000394511.1 hypothetical protein -
ILQ52_RS19035 3668436..3668621 - 186 WP_001133046.1 hypothetical protein -
ILQ52_RS19040 3669195..3669383 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ52_RS19045 3669380..3669571 + 192 WP_001098307.1 DUF1482 family protein -
ILQ52_RS19050 3669665..3672136 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175782 WP_001303876.1 NZ_CP062725:3666998-3667285 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175782 NZ_CP082202:251102-251884 [Streptococcus suis]
ATGAGGTTGGAAGAATTTAGTGAGGCTGACTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCTTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATCTTACTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCTAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAAGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGCTGATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTCTTAGCTTCGA
AAGGATACCAAGTTTCTTTAGCTGTCATTGGTACTAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATTGATCCCAATCAGGCCAGAGCAACACCAAAAGAACACCATGATGGGATTGTTGAGAACTTGGTTGATAA
CCTAAGCGAGTTAGAAAGAGAGCAACTCTTTGACTGTATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
AAACGTATGAAGGTTCCGCAGCAGAAGTGTTACAAGAATACCTCTTTGGAAAATGGAGTAAAGTCGAGGAAGAGATGTTG
AAGATGGGGCAGGAACGGTTGAGGGAATTGAACAAAGGAAGTAATAAGGGAATGGAGAGATAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175782 WP_000536233.1 NZ_CP062725:3666807-3666998 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175782 NZ_CP082202:250626-251102 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCAGACACACGATTTAACACAACCAGAATTTGCTAAAATGGTCGGTATTTC
ACGCAATAGCCTGAGTCGTTATGAAAATGGGACCAGTACGGTTTCAACAGAGCTTATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGACAAGATGTTAACACCTGTTGAAGATTACCAATTGACTTTAAAAGTAGAA
GTGATTAAAGAACGTGGAGCAGCCATTTTATCGCAGCTCTATCGATATCAAGATAGTCAGGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTCTCATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATTTACCTTGTCGATACTTTCGATG
AAATTGAGCGTTACAATGGCTATTTAGACGGTATTGAGCGGATGTTAGATATGGTACATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References