Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3584585..3585063 Replicon chromosome
Accession NZ_CP062723
Organism Escherichia coli O157:H7 strain Z1814

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ53_RS18435 Protein ID WP_001303876.1
Coordinates 3584776..3585063 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ53_RS18430 Protein ID WP_000536233.1
Coordinates 3584585..3584776 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ53_RS18395 3579989..3580759 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ53_RS18400 3580781..3581527 - 747 WP_000788751.1 ATP-binding protein -
ILQ53_RS18405 3581534..3582625 - 1092 WP_001205823.1 hypothetical protein -
ILQ53_RS18410 3582704..3583159 + 456 WP_000273724.1 hypothetical protein -
ILQ53_RS18415 3583366..3583791 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ53_RS18420 3583775..3584047 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ53_RS18425 3584156..3584557 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ53_RS18430 3584585..3584776 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ53_RS18435 3584776..3585063 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ53_RS18440 3585341..3585496 + 156 WP_000379575.1 DUF1391 family protein -
ILQ53_RS18445 3585638..3586027 + 390 WP_000394511.1 hypothetical protein -
ILQ53_RS18450 3586214..3586399 - 186 WP_001133046.1 hypothetical protein -
ILQ53_RS18455 3586973..3587161 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ53_RS18460 3587158..3587349 + 192 WP_001098307.1 DUF1482 family protein -
ILQ53_RS18465 3587443..3589914 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175746 WP_001303876.1 NZ_CP062723:3584776-3585063 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175746 NZ_CP082164:9136875-9137795 [Bradyrhizobium sp. 186]
ATGGCCAAGGTTCTCAAGAATCTCGCGGCGTCAATCAGGGACCGCCTGCTTCAACATACCAAGCAACATGGTGATGTCTA
TCAACGAATCCTGACGCGTTACGCGATCGAACGCCTGCTCTTCCGTCTTAGCCTGACGGAAGCGGCCGAGCATTATGTGC
TTAAGGGCGCGATGCTGTTCGTGACCTGGCCTGAACACGTCTTCAGGCCAACCGGTGATCTCGATCTGCTCGGCCACGGC
GACCCCGAGCCCGCCGCCATCGTTGAGCTCTTCACCCGCATCTGCCAAGTCGAAGCGCCCGATGACGGTATCATCTTCGA
TCCGGCCACTCTCACGGTCGAACCGGTGCGTGAAGGTGACAAGTACCAGGGCGTTCACCTGAATTTAAAGGGAGAGCTGG
CCAGGGCAGTGATTCCCGTTCAGGTTGATATTGGCTTTGGCGATCATGTCTATCCACCGCCGGAGCGCAGGATGTTCCCC
TGCCTTCTGCCGAACCTTCCGGCGGCGAATATTCTCATGTACCCGCCCGAAACTGTGATCGCAGAGAAATTCGAAGTGAT
GATCCGCTTCGGGACAGCGAATGGGCGGATCAAGGACTTCTACGACATTTGGGTCACGCTCCGCACATTCGGGTTCGAAC
TGCCCGAACTGGTGGAGGCCGTCGGCGGTACGCTCCGGCGCCGAGAGACTGCTGTCCCGACCGAGATACCTGTGGGATTG
ACCGAGGCGTTCGCTACGATTGCCGCCGATCGCGGTCTCTGGACTGGCTTTCTTCGTCGAAATCTGCCGACTATTCAGCC
GCCCTCTTTCCCAGAGCTTCAGCTGGAATTGCAACGGTTTCTGGGCCCTGTGATCACCGGTCTCGCGGTGCCGGAAGGGG
CCAAGGGCCGATGGGACCCGGATGGCGGGGCCTGGGTTTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175746 WP_000536233.1 NZ_CP062723:3584585-3584776 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175746 NZ_CP082164:9136561-9136875 [Bradyrhizobium sp. 186]
ATGACGATACCACACAAGGCGCGGACGCCGAACGCCCAAGTCATGCGGCTCGAGATCGTCCGGGCGACCGGAGATGTCCT
GACGGCGGGGGTCGAGCACGTCAGGGTCGAAGGCGTAGATGTGCCGATCTATGGCGTCGCGAAAACAATTGCCGATTGCT
TCAAACATCGCCGTCACGTCGGCGAGGACGTCGCCATCGAAGCTCTCCGAGACGCTCTGCGGCAACGAAAGACCACGGAG
AGTGAGCTCATGAAGTACGCAGGCATCGACCGTGTCACAGCGCGAATCGAGCCCTACATCAAAGCGATGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References