Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3594245..3594723 Replicon chromosome
Accession NZ_CP062708
Organism Escherichia coli O157:H7 strain Z1832

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ILQ60_RS18495 Protein ID WP_001303876.1
Coordinates 3594436..3594723 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ILQ60_RS18490 Protein ID WP_000536233.1
Coordinates 3594245..3594436 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ILQ60_RS18455 3589649..3590419 - 771 WP_000450992.1 DUF1627 domain-containing protein -
ILQ60_RS18460 3590441..3591187 - 747 WP_000788751.1 ATP-binding protein -
ILQ60_RS18465 3591194..3592285 - 1092 WP_001205823.1 hypothetical protein -
ILQ60_RS18470 3592364..3592819 + 456 WP_000273724.1 hypothetical protein -
ILQ60_RS18475 3593026..3593451 - 426 WP_000693855.1 Rha family transcriptional regulator -
ILQ60_RS18480 3593435..3593707 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ILQ60_RS18485 3593816..3594217 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ILQ60_RS18490 3594245..3594436 + 192 WP_000536233.1 hypothetical protein Antitoxin
ILQ60_RS18495 3594436..3594723 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ILQ60_RS18500 3595001..3595156 + 156 WP_000379575.1 DUF1391 family protein -
ILQ60_RS18505 3595298..3595687 + 390 WP_000394511.1 hypothetical protein -
ILQ60_RS18510 3595874..3596059 - 186 WP_001133046.1 hypothetical protein -
ILQ60_RS18515 3596633..3596821 + 189 WP_000413705.1 cell division inhibition protein DicB -
ILQ60_RS18520 3596818..3597009 + 192 WP_001098307.1 DUF1482 family protein -
ILQ60_RS18525 3597103..3599574 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T175492 WP_001303876.1 NZ_CP062708:3594436-3594723 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T175492 NZ_CP082010:4206180-4206398 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT175492 WP_000536233.1 NZ_CP062708:3594245-3594436 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT175492 NZ_CP082010:4205779-4206153 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References