Detailed information of TA system TA175220

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2292594..2292778
• Replicon: chromosome
• Accession: NZ_CP062420
• Organism: Staphylococcus aureus strain NAS_AN_016

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF696_RS11250
• Protein ID: WP_000482647.1
• Coordinates: 2292594..2292701 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2292718..2292778 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF696_RS11225	2287966..2288439	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF696_RS11230	2288562..2289773	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF696_RS11235	2289955..2290614	-	660	WP_000831298.1	membrane protein	-
IF696_RS11240	2290674..2291816	-	1143	WP_001176863.1	glycerate kinase	-
IF696_RS11245	2292074..2292460	+	387	WP_000779360.1	flippase GtxA	-
IF696_RS11250	2292594..2292701	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2292718..2292778	-	61	-	-	Antitoxin
IF696_RS11255	2293405..2295168	+	1764	WP_001064814.1	ABC transporter ATP-binding protein	-
IF696_RS11260	2295193..2296926	+	1734	WP_000486489.1	ABC transporter ATP-binding protein	-
IF696_RS11265	2297157..2297324	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T175220 WP_000482647.1 NZ_CP062420:2292594-2292701 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175220 NZ_CP081820:c5382596-5382213 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175220 NZ_CP062420:c2292778-2292718 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin