Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 1613429..1613958 Replicon chromosome
Accession NZ_CP062416
Organism Staphylococcus aureus strain NAS_AN_149

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF719_RS08010 Protein ID WP_001103933.1
Coordinates 1613429..1613746 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2X2M557
Locus tag IF719_RS08015 Protein ID WP_001058488.1
Coordinates 1613749..1613958 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF719_RS07985 (1608544) 1608544..1608885 - 342 WP_001190614.1 hypothetical protein -
IF719_RS07990 (1609421) 1609421..1610062 - 642 WP_064140196.1 pathogenicity island protein -
IF719_RS07995 (1610059) 1610059..1610439 - 381 WP_000356927.1 hypothetical protein -
IF719_RS08000 (1610770) 1610770..1612479 - 1710 WP_000447454.1 DUF927 domain-containing protein -
IF719_RS08005 (1612493) 1612493..1613362 - 870 WP_001002701.1 primase alpha helix C-terminal domain-containing protein -
IF719_RS08010 (1613429) 1613429..1613746 - 318 WP_001103933.1 DUF1474 family protein Toxin
IF719_RS08015 (1613749) 1613749..1613958 - 210 WP_001058488.1 hypothetical protein Antitoxin
IF719_RS08020 (1613951) 1613951..1614097 - 147 WP_000780975.1 hypothetical protein -
IF719_RS08025 (1614144) 1614144..1614404 - 261 WP_001147662.1 hypothetical protein -
IF719_RS08030 (1614406) 1614406..1614603 - 198 WP_000466891.1 helix-turn-helix transcriptional regulator -
IF719_RS08035 (1614747) 1614747..1615370 + 624 WP_000431539.1 helix-turn-helix transcriptional regulator -
IF719_RS08040 (1615466) 1615466..1616602 + 1137 WP_000592973.1 site-specific integrase -
IF719_RS08045 (1616696) 1616696..1618237 - 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sell / sec 1595861..1621034 25173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T175158 WP_001103933.1 NZ_CP062416:c1613746-1613429 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T175158 NZ_CP081785:23070-23381 [Escherichia coli]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8287.31 Da        Isoelectric Point: 4.2820

>AT175158 WP_001058488.1 NZ_CP062416:c1613958-1613749 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT175158 NZ_CP081785:23378-23797 [Escherichia coli]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTTCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2M557

References