Detailed information of TA system TA175083

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2311538..2311722
• Replicon: chromosome
• Accession: NZ_CP062412
• Organism: Staphylococcus aureus strain NAS_AN_181

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF725_RS11245
• Protein ID: WP_000482650.1
• Coordinates: 2311538..2311645 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2311662..2311722 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF725_RS11220	2306910..2307383	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF725_RS11225	2307506..2308717	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF725_RS11230	2308899..2309558	-	660	WP_000831298.1	membrane protein	-
IF725_RS11235	2309618..2310760	-	1143	WP_001176863.1	glycerate kinase	-
IF725_RS11240	2311018..2311404	+	387	WP_000779358.1	flippase GtxA	-
IF725_RS11245	2311538..2311645	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2311662..2311722	-	61	-	-	Antitoxin
IF725_RS11250	2312293..2314056	+	1764	WP_001064820.1	ABC transporter ATP-binding protein	-
IF725_RS11255	2314081..2315814	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF725_RS11260	2316045..2316212	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T175083 WP_000482650.1 NZ_CP062412:2311538-2311645 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T175083 NZ_CP081767:775344-775640 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT175083 NZ_CP062412:c2311722-2311662 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin