Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2311993..2312177 Replicon chromosome
Accession NZ_CP062395
Organism Staphylococcus aureus strain NAS_AN_005

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag IF694_RS11180 Protein ID WP_000482647.1
Coordinates 2311993..2312100 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2312117..2312177 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF694_RS11155 (IF694_11030) 2307355..2307828 + 474 WP_000456493.1 GyrI-like domain-containing protein -
IF694_RS11160 (IF694_11035) 2307951..2309162 - 1212 WP_001191927.1 multidrug effflux MFS transporter -
IF694_RS11165 (IF694_11040) 2309344..2310003 - 660 WP_031927729.1 membrane protein -
IF694_RS11170 (IF694_11045) 2310063..2311205 - 1143 WP_001176870.1 glycerate kinase -
IF694_RS11175 (IF694_11050) 2311473..2311859 + 387 WP_000779353.1 flippase GtxA -
IF694_RS11180 (IF694_11055) 2311993..2312100 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2312117..2312177 - 61 - - Antitoxin
IF694_RS11185 (IF694_11060) 2312804..2314567 + 1764 WP_031927727.1 ABC transporter ATP-binding protein -
IF694_RS11190 (IF694_11065) 2314592..2316325 + 1734 WP_000486497.1 ABC transporter ATP-binding protein -
IF694_RS11195 (IF694_11070) 2316556..2316723 + 168 WP_031927726.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T174841 WP_000482647.1 NZ_CP062395:2311993-2312100 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T174841 NZ_CP081690:2935549-2935656 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 61 bp

>AT174841 NZ_CP062395:c2312177-2312117 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References