Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2752086..2752615 Replicon chromosome
Accession NZ_CP062390
Organism Staphylococcus aureus strain NAS_AN_036

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag IF699_RS13660 Protein ID WP_001103933.1
Coordinates 2752298..2752615 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag IF699_RS13655 Protein ID WP_001058487.1
Coordinates 2752086..2752295 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF699_RS13620 (2747317) 2747317..2747601 + 285 WP_000917289.1 co-chaperone GroES -
IF699_RS13625 (2747677) 2747677..2749293 + 1617 WP_000240642.1 chaperonin GroEL -
IF699_RS13630 (2749362) 2749362..2750534 - 1173 WP_000179353.1 tyrosine-type recombinase/integrase -
IF699_RS13635 (2750548) 2750548..2751255 - 708 WP_223289515.1 helix-turn-helix transcriptional regulator -
IF699_RS13640 (2751423) 2751423..2751629 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
IF699_RS13645 (2751633) 2751633..2751950 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
IF699_RS13650 (2751947) 2751947..2752093 + 147 WP_000708434.1 hypothetical protein -
IF699_RS13655 (2752086) 2752086..2752295 + 210 WP_001058487.1 hypothetical protein Antitoxin
IF699_RS13660 (2752298) 2752298..2752615 + 318 WP_001103933.1 DUF1474 family protein Toxin
IF699_RS13665 (2752682) 2752682..2753551 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
IF699_RS13670 (2753568) 2753568..2755037 + 1470 WP_001838755.1 virulence-associated E family protein -
IF699_RS13675 (2755323) 2755323..2755685 + 363 WP_001039169.1 hypothetical protein -
IF699_RS13680 (2755687) 2755687..2755971 + 285 WP_000998179.1 hypothetical protein -
IF699_RS13685 (2755968) 2755968..2756609 + 642 WP_001019811.1 hypothetical protein -
IF699_RS13690 (2757145) 2757145..2757486 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T174820 WP_001103933.1 NZ_CP062390:2752298-2752615 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T174820 NZ_CP081684:c4337695-4337345 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT174820 WP_001058487.1 NZ_CP062390:2752086-2752295 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT174820 NZ_CP081684:c4337940-4337689 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References