Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2271515..2272038 Replicon chromosome
Accession NZ_CP062376
Organism Staphylococcus aureus strain NAS_AN_099

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag IF707_RS10995 Protein ID WP_045177693.1
Coordinates 2271772..2272038 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag IF707_RS10990 Protein ID WP_000587618.1
Coordinates 2271515..2271772 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF707_RS10975 (2268011) 2268011..2268760 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
IF707_RS10980 (2268955) 2268955..2270532 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF707_RS10985 (2270700) 2270700..2271155 - 456 WP_000732090.1 YehR family lipoprotein -
IF707_RS10990 (2271515) 2271515..2271772 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF707_RS10995 (2271772) 2271772..2272038 + 267 WP_045177693.1 Txe/YoeB family addiction module toxin Toxin
IF707_RS11000 (2272394) 2272394..2273470 + 1077 WP_001076673.1 M42 family metallopeptidase -
IF707_RS11005 (2273718) 2273718..2274380 + 663 WP_045177691.1 ATP-binding cassette domain-containing protein -
IF707_RS11010 (2274373) 2274373..2275149 + 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
IF707_RS11015 (2275545) 2275545..2276732 + 1188 WP_045177690.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10684.35 Da        Isoelectric Point: 10.1384

>T174693 WP_045177693.1 NZ_CP062376:2271772-2272038 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174693 NZ_CP081351:c5268705-5268352 [Klebsiella michiganensis]
ATGCAAACCCAATCATCTCCCCTCGTGCGGGCGGCATCGTCACGTCCGTCTCCCGTGGGTGTCTGGCAGACCCTGCTGAC
CTGCCTGCTGGAACACCACTATGGCCTCACGCTTAACGATACGCCGTTCAGTGATGAACAGGTGATTCAGCAGCATATCG
ACGCGGGTATCTCGCTGTGCGATGCCCTGAATTTCATTGTTGAAAAGTACGAACTGCTCCGCACTGACCGGCCAGGCTTC
AGCATCAGGGAGCAGTCTCCGTTTATCACACCCATAGATATCCTCCGGGCCAGAAAGGCTACGGGGCTGATGAACTGTGG
CACGTATAAAGAGGTGACGGCTATTACCAGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT174693 WP_000587618.1 NZ_CP062376:2271515-2271772 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174693 NZ_CP081351:c5269087-5268761 [Klebsiella michiganensis]
ATCAGCGAACCCTGGTGGGGGCTAAGACGCAGTGTCTCCCCGTGTTTTGGGGCCCGTCTGGTCCAGGAGGGAAACCGCCT
GCATTACCTGGCTGACCGGGCAAACTTTGACGGTCAGTTCTGCGATGCGGATTTGCGCCATCTTGACCAGGCTTTCCCGG
TATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTAAATCCCCGTCATCAGCACTGCGTCACACTGTATGCA
AAAGGTCTGACCTGCGAGGCCGATACGCTCGGTTCGCACGGTTACGTTTATATCGCGATTTATCCCACTCCTGTCGCCAC
GGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References