Detailed information of TA system TA174686

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20493..20831
• Replicon: chromosome
• Accession: NZ_CP062376
• Organism: Staphylococcus aureus strain NAS_AN_099

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF707_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20493..20669 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20657..20831 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF707_RS00085	18323..18475	+	153	WP_001000058.1	hypothetical protein	-
IF707_RS00090	18521..18808	+	288	WP_001262621.1	hypothetical protein	-
IF707_RS00095	18864..19238	+	375	WP_000340977.1	hypothetical protein	-
IF707_RS00100	19611..20384	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
IF707_RS00105	20493..20669	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20657..20831	-	175	-	-	Antitoxin
IF707_RS00115	20881..21135	+	255	WP_000611512.1	phage holin	-
IF707_RS00120	21147..21902	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF707_RS00125	22093..22584	+	492	WP_000920038.1	staphylokinase	-
IF707_RS00130	23235..23570	+	336	Protein_25	SH3 domain-containing protein	-
IF707_RS00135	24081..24431	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF707_RS00140	24484..24744	-	261	WP_001791826.1	hypothetical protein	-
IF707_RS00145	25055..25234	-	180	WP_000669791.1	hypothetical protein	-
IF707_RS00150	25606..25803	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / sak / scn	52..24431	24379

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174686 WP_011447039.1 NZ_CP062376:20493-20669 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174686 NZ_CP081351:40577-40918 [Klebsiella michiganensis]
ATGTGGGATGTTGAAACAACGGAGGTTTTTGACAAGTGGTTTGAGGCGCAGACCGAAGCGCTCAAAGAGGATATGCTCGC
CGCAATGGTGATCTTATCCGAGTATGGCCCCCGGTTGGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCCTTTTCGA
ATATGAAAGAGCTGCGCATTCAGCATCAAGGTAGACCCATCCGAGCTTTCTTTGTATTTGACCCTTCTCGTTGTGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174686 NZ_CP062376:c20831-20657 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin