Detailed information of TA system TA174608

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2297779..2297963
• Replicon: chromosome
• Accession: NZ_CP062362
• Organism: Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF721_RS11195
• Protein ID: WP_000482650.1
• Coordinates: 2297779..2297886 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2297903..2297963 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF721_RS11170	2293151..2293624	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF721_RS11175	2293747..2294958	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF721_RS11180	2295140..2295799	-	660	WP_000831298.1	membrane protein	-
IF721_RS11185	2295859..2297001	-	1143	WP_001176863.1	glycerate kinase	-
IF721_RS11190	2297259..2297645	+	387	WP_000779358.1	flippase GtxA	-
IF721_RS11195	2297779..2297886	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2297903..2297963	-	61	-	-	Antitoxin
IF721_RS11200	2298534..2300297	+	1764	WP_001064820.1	ABC transporter ATP-binding protein	-
IF721_RS11205	2300322..2302055	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF721_RS11210	2302286..2302453	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174608 WP_000482650.1 NZ_CP062362:2297779-2297886 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174608 NZ_CP081203:c12429-12052 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174608 NZ_CP062362:c2297963-2297903 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin