Detailed information of TA system TA174490

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 1929937..1930134
• Replicon: chromosome
• Accession: NZ_CP062348
• Organism: Staphylococcus aureus strain NAS_AN_260

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF738_RS09835
• Protein ID: WP_001802298.1
• Coordinates: 1930030..1930134 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1929937..1929975 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF738_RS09810	1926121..1926786	-	666	WP_001024095.1	SDR family oxidoreductase	-
IF738_RS09815	1926938..1927258	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF738_RS09820	1927260..1928240	+	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF738_RS09825	1928506..1929597	+	1092	WP_000495683.1	hypothetical protein	-
IF738_RS09830	1929917..1929991	+	75	Protein_1898	hypothetical protein	-
-	1929937..1929975	+	39	-	-	Antitoxin
IF738_RS09835	1930030..1930134	-	105	WP_001802298.1	hypothetical protein	Toxin
IF738_RS09840	1930814..1930972	+	159	WP_001792784.1	hypothetical protein	-
IF738_RS09845	1931631..1932488	-	858	WP_000370917.1	HAD family hydrolase	-
IF738_RS09850	1932556..1933338	-	783	WP_000908178.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174490 WP_001802298.1 NZ_CP062348:c1930134-1930030 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174490 NZ_CP081012:13238-13519 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATTA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT174490 NZ_CP062348:1929937-1929975 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin