Detailed information of TA system TA174447

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 504890..505469
• Replicon: chromosome
• Accession: NZ_CP062344
• Organism: Staphylococcus aureus strain NAS_AN_265

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: IF740_RS02725
• Protein ID: WP_001025401.1
• Coordinates: 504890..505135 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	505104..505469 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF740_RS02675 (501011)	501011..501625	+	615	WP_031844332.1	hypothetical protein	-
IF740_RS02680 (501622)	501622..501768	-	147	WP_001013104.1	hypothetical protein	-
IF740_RS02685 (501804)	501804..501986	-	183	WP_000705243.1	hypothetical protein	-
IF740_RS02690 (502186)	502186..502917	-	732	WP_031793402.1	XRE family transcriptional regulator	-
IF740_RS02695 (503069)	503069..503281	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
IF740_RS02700 (503329)	503329..503772	+	444	WP_000435357.1	hypothetical protein	-
IF740_RS02705 (503787)	503787..503936	+	150	WP_000771849.1	hypothetical protein	-
IF740_RS02710 (503977)	503977..504189	-	213	WP_000362644.1	hypothetical protein	-
IF740_RS02715 (504259)	504259..504456	+	198	WP_001148860.1	hypothetical protein	-
IF740_RS02720 (504443)	504443..504823	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
IF740_RS02725 (504890)	504890..505135	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
IF740_RS02730 (505104)	505104..505469	-	366	WP_001128433.1	hypothetical protein	Antitoxin
IF740_RS02735 (505524)	505524..505739	+	216	WP_001097553.1	hypothetical protein	-
IF740_RS02740 (505764)	505764..506027	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
IF740_RS02745 (506039)	506039..506200	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
IF740_RS02750 (506279)	506279..506602	+	324	WP_000174998.1	hypothetical protein	-
IF740_RS02755 (506617)	506617..506979	+	363	WP_000279448.1	hypothetical protein	-
IF740_RS02760 (506976)	506976..508142	+	1167	WP_000762531.1	DUF2800 domain-containing protein	-
IF740_RS02765 (508168)	508168..508725	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T174447 WP_001025401.1 NZ_CP062344:504890-505135 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T174447 NZ_CP081009:2520304-2520618 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT174447 NZ_CP062344:c505469-505104 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin