Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 168580..169230 Replicon chromosome
Accession NZ_CP062310
Organism Infirmifilum lucidum strain 3507LT

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IG193_RS00970 Protein ID WP_192819042.1
Coordinates 168820..169230 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IG193_RS00965 Protein ID WP_192819041.1
Coordinates 168580..168813 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG193_RS00945 (IG193_00945) 163853..164575 - 723 WP_192819037.1 hypothetical protein -
IG193_RS00950 (IG193_00950) 164700..166016 + 1317 WP_192819038.1 ATP-binding protein -
IG193_RS00955 (IG193_00955) 166097..167029 - 933 WP_192819039.1 hypothetical protein -
IG193_RS00960 (IG193_00960) 167551..168249 - 699 WP_192819040.1 hypothetical protein -
IG193_RS00965 (IG193_00965) 168580..168813 + 234 WP_192819041.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
IG193_RS00970 (IG193_00970) 168820..169230 + 411 WP_192819042.1 type II toxin-antitoxin system VapC family toxin Toxin
IG193_RS00975 (IG193_00975) 169308..170663 + 1356 WP_192819043.1 serine hydrolase -
IG193_RS00980 (IG193_00980) 170714..173398 - 2685 WP_192819044.1 cation-transporting P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(4-115)

Antitoxin

Post-segregation antitoxin CcdA

(9-65)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15203.45 Da        Isoelectric Point: 4.3969

>T174197 WP_192819042.1 NZ_CP062310:168820-169230 [Infirmifilum lucidum]
VYLLDSSALYPLVLALGEGVLDVAGRVSILTLTPYEVGNAVWKEYRAGGIKRLEPVVELFSSILGEFRRVDPLEYWSSIL
SLAVRENLSFYDASYLYVSRVLGLVLVSEDSDLKKYPDVISVREFIDRLRAPDEGG

Download         Length: 411 bp

>T174197 NZ_CP080584:2024447-2024549 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9087.40 Da        Isoelectric Point: 5.3427

>AT174197 WP_192819041.1 NZ_CP062310:168580-168813 [Infirmifilum lucidum]
MREAPTEVVSVRVRRELKEEARALGINLREVVERAIEEEVRRVKREKFRRLLGEALEAMDVSVEEWVRAVEGDRAER

Download         Length: 234 bp

>AT174197 NZ_CP080584:c2024556-2024411 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References