Detailed information of TA system TA174197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-CcdA
• Location: 168580..169230
• Replicon: chromosome
• Accession: NZ_CP062310
• Organism: Infirmifilum lucidum strain 3507LT

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IG193_RS00970
• Protein ID: WP_192819042.1
• Coordinates: 168820..169230 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IG193_RS00965
• Protein ID: WP_192819041.1
• Coordinates: 168580..168813 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IG193_RS00945 (IG193_00945)	163853..164575	-	723	WP_192819037.1	hypothetical protein	-
IG193_RS00950 (IG193_00950)	164700..166016	+	1317	WP_192819038.1	ATP-binding protein	-
IG193_RS00955 (IG193_00955)	166097..167029	-	933	WP_192819039.1	hypothetical protein	-
IG193_RS00960 (IG193_00960)	167551..168249	-	699	WP_192819040.1	hypothetical protein	-
IG193_RS00965 (IG193_00965)	168580..168813	+	234	WP_192819041.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
IG193_RS00970 (IG193_00970)	168820..169230	+	411	WP_192819042.1	type II toxin-antitoxin system VapC family toxin	Toxin
IG193_RS00975 (IG193_00975)	169308..170663	+	1356	WP_192819043.1	serine hydrolase	-
IG193_RS00980 (IG193_00980)	170714..173398	-	2685	WP_192819044.1	cation-transporting P-type ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (4-115)

Antitoxin

• Post-segregation antitoxin CcdA (9-65)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15203.45 Da
• Isoelectric Point: 4.3969

>T174197 WP_192819042.1 NZ_CP062310:168820-169230 [Infirmifilum lucidum]
VYLLDSSALYPLVLALGEGVLDVAGRVSILTLTPYEVGNAVWKEYRAGGIKRLEPVVELFSSILGEFRRVDPLEYWSSIL
SLAVRENLSFYDASYLYVSRVLGLVLVSEDSDLKKYPDVISVREFIDRLRAPDEGG

Nucleotide

• Length: 411 bp

>T174197 NZ_CP080584:2024447-2024549 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9087.40 Da
• Isoelectric Point: 5.3427

>AT174197 WP_192819041.1 NZ_CP062310:168580-168813 [Infirmifilum lucidum]
MREAPTEVVSVRVRRELKEEARALGINLREVVERAIEEEVRRVKREKFRRLLGEALEAMDVSVEEWVRAVEGDRAER

Nucleotide

• Length: 234 bp

>AT174197 NZ_CP080584:c2024556-2024411 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT