Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3949098..3949641 Replicon chromosome
Accession NZ_CP062204
Organism Escherichia coli strain C311

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag IG172_RS19355 Protein ID WP_192291818.1
Coordinates 3949360..3949641 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag IG172_RS19350 Protein ID WP_124074528.1
Coordinates 3949098..3949379 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IG172_RS19325 3944134..3945273 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
IG172_RS19330 3945257..3947350 + 2094 WP_047082124.1 flagellar biosynthesis protein FlhA -
IG172_RS19335 3947455..3947733 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
IG172_RS19340 3947726..3948082 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
IG172_RS19345 3948139..3948912 - 774 WP_000543899.1 C40 family peptidase -
IG172_RS19350 3949098..3949379 + 282 WP_124074528.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IG172_RS19355 3949360..3949641 + 282 WP_192291818.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IG172_RS19360 3949797..3950537 + 741 WP_001225679.1 murein L,D-transpeptidase -
IG172_RS19365 3950508..3951275 - 768 WP_000333380.1 class II glutamine amidotransferase -
IG172_RS19370 3951481..3952059 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10944.77 Da        Isoelectric Point: 10.1975

>T173518 WP_192291818.1 NZ_CP062204:3949360-3949641 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLL
RFERTGTHAALFG

Download         Length: 282 bp

>T173518 NZ_CP080235:c1315800-1315546 [Escherichia coli O139:H1]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10339.77 Da        Isoelectric Point: 5.1392

>AT173518 WP_124074528.1 NZ_CP062204:3949098-3949379 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLEFKYDSKGY

Download         Length: 282 bp

>AT173518 NZ_CP080235:c1316048-1315797 [Escherichia coli O139:H1]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCTGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References