173356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 92156..92678 Replicon plasmid unnamed2
Accession NZ_CP061977
Organism Klebsiella pneumoniae strain IR5086

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag H4I67_RS26145 Protein ID WP_004181778.1
Coordinates 92394..92678 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag H4I67_RS26140 Protein ID WP_025368601.1
Coordinates 92156..92404 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4I67_RS26120 87365..88186 - 822 WP_004026535.1 hypothetical protein -
H4I67_RS26125 88248..88601 - 354 WP_004181774.1 hypothetical protein -
H4I67_RS26130 88746..89732 - 987 WP_025368599.1 hypothetical protein -
H4I67_RS26135 90066..91865 - 1800 WP_025368600.1 ATP-dependent helicase -
H4I67_RS26140 92156..92404 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H4I67_RS26145 92394..92678 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H4I67_RS26150 92908..94134 + 1227 WP_025368602.1 transposase -
H4I67_RS26155 94420..94845 - 426 WP_040120489.1 IS200/IS605 family transposase -
H4I67_RS26160 94882..96108 + 1227 WP_025368604.1 transposase -
H4I67_RS26165 96174..97300 - 1127 Protein_99 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(B) / ant(3'')-Ia / qacE / sul1 / aph(3')-Ia rmpA2 / iutA / iucD / iucC / iucB / iucA / rmpA 1..266729 266729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T173356 WP_004181778.1 NZ_CP061977:92394-92678 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T173356 NZ_CP080146:c4835208-4834813 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATATCACGTTC
AGGAAACCAGAACTGGTTGACAGGCTTAATGATATTATTGCCAGACACTACTCGGAAGCCCTGGCAAGCACAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT173356 WP_025368601.1 NZ_CP061977:92156-92404 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT173356 NZ_CP080146:c4835629-4835255 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References