Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | stbDE/ParE-DnaT |
| Location | 207032..207554 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP061962 | ||
| Organism | Klebsiella pneumoniae strain JNK002 | ||
Toxin (Protein)
| Gene name | stbE | Uniprot ID | A0A2J4R0S6 |
| Locus tag | H4I73_RS27920 | Protein ID | WP_004181778.1 |
| Coordinates | 207270..207554 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | stbD | Uniprot ID | A0A5Q9LM53 |
| Locus tag | H4I73_RS27915 | Protein ID | WP_025368601.1 |
| Coordinates | 207032..207280 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H4I73_RS27895 | 202242..203063 | - | 822 | WP_004026535.1 | hypothetical protein | - |
| H4I73_RS27900 | 203125..203478 | - | 354 | WP_004181774.1 | hypothetical protein | - |
| H4I73_RS27905 | 203623..204609 | - | 987 | WP_025368599.1 | hypothetical protein | - |
| H4I73_RS27910 | 204943..206742 | - | 1800 | WP_088678991.1 | ATP-dependent helicase | - |
| H4I73_RS27915 | 207032..207280 | + | 249 | WP_025368601.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| H4I73_RS27920 | 207270..207554 | + | 285 | WP_004181778.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H4I73_RS27925 | 207784..209010 | + | 1227 | WP_025368602.1 | transposase | - |
| H4I73_RS27930 | 209296..209721 | - | 426 | WP_040120489.1 | IS200/IS605 family transposase | - |
| H4I73_RS27935 | 209758..210984 | + | 1227 | WP_025368604.1 | transposase | - |
| H4I73_RS27940 | 211050..212176 | - | 1127 | Protein_220 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul1 / qacE / ant(3'')-Ia / ant(2'')-Ia / blaSHV-2 / catA1 | rmpA / iutA / iucD / iucC / iucB / iucA | 1..307252 | 307252 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10970.69 Da Isoelectric Point: 10.6516
>T173294 WP_004181778.1 NZ_CP061962:207270-207554 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN
Download Length: 285 bp
>T173294 NZ_CP080133:2597915-2598022 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8906.12 Da Isoelectric Point: 3.8206
>AT173294 WP_025368601.1 NZ_CP061962:207032-207280 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL
Download Length: 249 bp
>AT173294 NZ_CP080133:c2597868-2597802 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4R0S6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LM53 |