Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 3950152..3950663 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag dnm_RS15325 Protein ID WP_207683502.1
Coordinates 3950152..3950412 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag dnm_RS15330 Protein ID WP_207683503.1
Coordinates 3950409..3950663 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS15280 (dnm_050070) 3945407..3946003 - 597 WP_207683494.1 translation elongation factor Ts -
dnm_RS15285 (dnm_050080) 3946009..3946938 - 930 WP_207683495.1 30S ribosomal protein S2 -
dnm_RS15290 (dnm_050110) 3947475..3947690 - 216 WP_207683496.1 hypothetical protein -
dnm_RS15295 (dnm_050120) 3947687..3947980 - 294 WP_246556336.1 DUF4258 domain-containing protein -
dnm_RS15300 (dnm_050130) 3948140..3948418 - 279 WP_207683497.1 putative addiction module antidote protein -
dnm_RS15305 (dnm_050155) 3948776..3949126 - 351 WP_207683498.1 type II toxin-antitoxin system PemK/MazF family toxin -
dnm_RS15310 (dnm_050160) 3949137..3949361 - 225 WP_207683499.1 hypothetical protein -
dnm_RS15315 (dnm_050170) 3949525..3949698 - 174 WP_207683500.1 hypothetical protein -
dnm_RS15325 (dnm_050190) 3950152..3950412 - 261 WP_207683502.1 Txe/YoeB family addiction module toxin Toxin
dnm_RS15330 (dnm_050200) 3950409..3950663 - 255 WP_207683503.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
dnm_RS15335 (dnm_050210) 3950933..3951763 - 831 WP_207683504.1 hypothetical protein -
dnm_RS15340 (dnm_050220) 3951882..3952667 - 786 WP_207683505.1 DUF1829 domain-containing protein -
dnm_RS15345 (dnm_050230) 3952678..3953166 - 489 WP_207683506.1 hypothetical protein -
dnm_RS15350 (dnm_050240) 3953208..3953369 - 162 WP_207683507.1 hypothetical protein -
dnm_RS15360 (dnm_050260) 3953947..3954837 - 891 WP_207683508.1 peptide chain release factor N(5)-glutamine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10380.97 Da        Isoelectric Point: 10.3180

>T173026 WP_207683502.1 NZ_CP061800:c3950412-3950152 [Desulfonema magnum]
MKVIFTEASWKDYLWFQENNRKLLKRINNFIKEIKRSPFEGTGKPEPLKANLSGYWSRRINSEHRLVYGVSEDKLTIISC
RFHYEK

Download         Length: 261 bp

>T173026 NZ_CP080080:2300602-2301924 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9356.50 Da        Isoelectric Point: 4.0202

>AT173026 WP_207683503.1 NZ_CP061800:c3950663-3950409 [Desulfonema magnum]
MNAVLTAQASKNLDNLIEQIVADAEPAILLNDKGEKAVLMSLDEFNSWQETLYLLSNPANAEHLRNSIQEANEGKTFEKE
LIEV

Download         Length: 255 bp

>AT173026 NZ_CP080080:2300336-2300602 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References