Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3566545..3567125 Replicon chromosome
Accession NZ_CP061771
Organism Salinibacterium sp. ZJ450

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HCT51_RS17290 Protein ID WP_166880412.1
Coordinates 3566727..3567125 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HCT51_RS17285 Protein ID WP_166880409.1
Coordinates 3566545..3566730 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCT51_RS17255 3562116..3562580 + 465 WP_166880481.1 ATP-binding protein -
HCT51_RS17260 3562622..3563419 + 798 WP_166880397.1 HAD-IIA family hydrolase -
HCT51_RS17265 3563545..3564369 - 825 WP_166880399.1 hypothetical protein -
HCT51_RS17270 3564366..3564917 - 552 WP_166880402.1 orotate phosphoribosyltransferase -
HCT51_RS17275 3565434..3565598 + 165 WP_166880404.1 hypothetical protein -
HCT51_RS17280 3565608..3566447 + 840 WP_166880407.1 exodeoxyribonuclease III -
HCT51_RS17285 3566545..3566730 + 186 WP_166880409.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HCT51_RS17290 3566727..3567125 + 399 WP_166880412.1 type II toxin-antitoxin system VapC family toxin Toxin
HCT51_RS17295 3567155..3568075 - 921 WP_166880415.1 AEC family transporter -
HCT51_RS17300 3568115..3568699 - 585 WP_166880418.1 PadR family transcriptional regulator -
HCT51_RS17305 3568794..3569462 + 669 WP_166880420.1 class II aldolase/adducin family protein -
HCT51_RS17310 3569462..3570367 + 906 WP_166880423.1 VOC family protein -
HCT51_RS17315 3570367..3570561 + 195 WP_166880425.1 tautomerase family protein -
HCT51_RS17320 3570750..3572102 + 1353 WP_166880427.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(1-60)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14152.71 Da        Isoelectric Point: 4.3461

>T172975 WP_166880412.1 NZ_CP061771:3566727-3567125 [Salinibacterium sp. ZJ450]
MIVDSSALIAIARQEPDAATYARALARSEASFLSAANYVEAAIVVDRSHDPIASRAFDDLLSLASIRIEPVTVEQARIAR
DAYRDFGEGSGHPAGLNFGDCFAYALAKDRGQPLLFKGDDFSQTDVQSALDS

Download         Length: 399 bp

>T172975 NZ_CP080066:3715591-3715869 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6866.59 Da        Isoelectric Point: 4.7778

>AT172975 WP_166880409.1 NZ_CP061771:3566545-3566730 [Salinibacterium sp. ZJ450]
VSQTRAVEDAVNRRLDELRRHAPEDKAERILAVGREIAGRLGPDSFGDVDDLLYDEHGLPR

Download         Length: 186 bp

>AT172975 NZ_CP080066:3715328-3715588 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References