Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
| Location | 4591519..4592312 | Replicon | chromosome |
| Accession | NZ_CP061749 | ||
| Organism | Escherichia coli O15:H12 strain 2273-PO3 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1EZ92 |
| Locus tag | IED00_RS22275 | Protein ID | WP_000854726.1 |
| Coordinates | 4591935..4592312 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EBQ7 |
| Locus tag | IED00_RS22270 | Protein ID | WP_001548930.1 |
| Coordinates | 4591519..4591845 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IED00_RS22225 | 4587006..4587650 | - | 645 | WP_001547746.1 | TetR/AcrR family transcriptional regulator | - |
| IED00_RS22230 | 4587925..4588622 | - | 698 | Protein_4380 | IS1 family transposase | - |
| IED00_RS22235 | 4588737..4588973 | + | 237 | WP_001144031.1 | hypothetical protein | - |
| IED00_RS22240 | 4588973..4589416 | + | 444 | WP_001547764.1 | phage transcriptional regulator | - |
| IED00_RS22245 | 4589439..4589906 | + | 468 | WP_001547765.1 | hypothetical protein | - |
| IED00_RS22250 | 4589983..4590222 | + | 240 | WP_000194654.1 | DUF905 domain-containing protein | - |
| IED00_RS22255 | 4590320..4590778 | + | 459 | WP_001548150.1 | antirestriction protein | - |
| IED00_RS22260 | 4590794..4591270 | + | 477 | WP_000811693.1 | RadC family protein | - |
| IED00_RS22265 | 4591279..4591500 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| IED00_RS22270 | 4591519..4591845 | + | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| IED00_RS22275 | 4591935..4592312 | + | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
| IED00_RS22280 | 4592309..4592797 | + | 489 | WP_001547769.1 | hypothetical protein | - |
| IED00_RS22285 | 4592809..4593006 | + | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
| IED00_RS22290 | 4593091..4593933 | + | 843 | WP_001547770.1 | DUF4942 domain-containing protein | - |
| IED00_RS22295 | 4594682..4596220 | + | 1539 | WP_001187177.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4587006..4604033 | 17027 | |
| - | flank | IS/Tn | - | - | 4587925..4588302 | 377 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T172898 WP_000854726.1 NZ_CP061749:4591935-4592312 [Escherichia coli O15:H12]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T172898 NZ_CP079993:2931868-2932242 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT172898 WP_001548930.1 NZ_CP061749:4591519-4591845 [Escherichia coli O15:H12]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT172898 NZ_CP079993:2931411-2931779 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|