Detailed information of TA system TA172896

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4374951..4375630
• Replicon: chromosome
• Accession: NZ_CP061749
• Organism: Escherichia coli O15:H12 strain 2273-PO3

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: IED00_RS21180
• Protein ID: WP_096889654.1
• Coordinates: 4374951..4375292 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: IED00_RS21185
• Protein ID: WP_096889656.1
• Coordinates: 4375313..4375630 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4369575..4383363	13788
	-	flank	IS/Tn	-	-	4371587..4372090	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-110)

Antitoxin

• Antitoxin CbeA (5-103)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12695.65 Da
• Isoelectric Point: 8.0307

>T172896 WP_096889654.1 NZ_CP061749:c4375292-4374951 [Escherichia coli O15:H12]
MKTLPATTPQAATLCLSPVAVWQMLLTRLLKQHYGLTLNDTPFSDETVIQEHIDAGITLANAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRINSNNSAL

Nucleotide

• Length: 342 bp

>T172896 NZ_CP079993:c2500261-2499974 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11856.37 Da
• Isoelectric Point: 6.4776

>AT172896 WP_096889656.1 NZ_CP061749:c4375630-4375313 [Escherichia coli O15:H12]
MSNTTWGLQRDITPRQGARLVQEGNRVHYLADRVSITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
DGFTCEADTLGSYGYVYIAIYPTHS

Nucleotide

• Length: 318 bp

>AT172896 NZ_CP079993:c2500500-2500261 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA