172820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 316559..317081 Replicon plasmid pC39-334kb
Accession NZ_CP061701
Organism Klebsiella pneumoniae strain C39

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag IE968_RS27290 Protein ID WP_004181778.1
Coordinates 316559..316843 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag IE968_RS27295 Protein ID WP_004181777.1
Coordinates 316833..317081 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE968_RS27265 314026..314304 - 279 WP_044349308.1 hypothetical protein -
IE968_RS27270 315103..315390 - 288 WP_044349311.1 helix-turn-helix transcriptional regulator -
IE968_RS27275 315395..315826 - 432 WP_044349313.1 hypothetical protein -
IE968_RS27280 315870..316052 - 183 WP_044349315.1 type II toxin-antitoxin system HicA family toxin -
IE968_RS27285 316146..316538 + 393 WP_052626761.1 type II toxin-antitoxin system PrlF family antitoxin -
IE968_RS27290 316559..316843 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE968_RS27295 316833..317081 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IE968_RS27300 317373..319172 + 1800 WP_064371185.1 ATP-dependent helicase -
IE968_RS27305 319501..320505 + 1005 WP_064371184.1 hypothetical protein -
IE968_RS27310 320641..320994 + 354 WP_042927270.1 hypothetical protein -
IE968_RS27315 321054..321911 + 858 WP_064371183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-1 / sul1 / blaVEB-3 / mph(A) / blaSFO-1 / aac(3)-IId / blaTEM-1B / ARR-3 / dfrA27 / qacE / qnrA7 katA 1..334893 334893


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T172820 WP_004181778.1 NZ_CP061701:c316843-316559 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T172820 NZ_CP079955:c1856457-1856107 [Macrococcus sp. 19Msa1099]
ATGAAACGCGGAGATGTTTATTTAGCTGATCTGTCACCAGTGAAGGGGTCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATTGGGAATAAACATAGTCCTACAGTGATTGTAGCAGCAATTACTGCAAAGATTAATAAGGCGAAAA
TCCCCACCCATGTTGAAATTGGCAAGACAACGCATCGCTTAGAAAAGGATTCGGTAATACTGCTGGAACAAATTAGAACC
ATTGATAAGAATAGGTTGATTGATCATTTAACTGTGCTTGATAAGGCGAAGATGAAAGAAGTGGATACTGCACTTATAAT
TAGTTTGGGTTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT172820 WP_004181777.1 NZ_CP061701:c317081-316833 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT172820 NZ_CP079955:c1856598-1856458 [Macrococcus sp. 19Msa1099]
ATGAGCCAGAAGCTAGAACAAATGCTGATAGAAGGTTATCAATCAATGGCAGAGATAAATTTATCGATAGCATCAGAACA
TTATGTATTAGAATGTGAAGTTACTGATAACTATCAGACATATACCTTTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References