172800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352405..353051 Replicon chromosome
Accession NZ_CP061700
Organism Klebsiella pneumoniae strain C39

Toxin (Protein)


Gene name higB Uniprot ID A0A486LFK7
Locus tag IE968_RS01625 Protein ID WP_023301313.1
Coordinates 352405..352752 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag IE968_RS01630 Protein ID WP_002920557.1
Coordinates 352752..353051 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE968_RS01615 348331..349764 + 1434 WP_002920564.1 glycogen synthase GlgA -
IE968_RS01620 349782..352229 + 2448 WP_002920561.1 glycogen phosphorylase -
IE968_RS01625 352405..352752 + 348 WP_023301313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE968_RS01630 352752..353051 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
IE968_RS01635 353114..354622 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
IE968_RS01640 354827..355156 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
IE968_RS01645 355207..356037 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
IE968_RS01650 356087..356845 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13506.49 Da        Isoelectric Point: 6.2327

>T172800 WP_023301313.1 NZ_CP061700:352405-352752 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITMADREFSQHLTKER

Download         Length: 348 bp

>T172800 NZ_CP079934:5480-5767 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT172800 WP_002920557.1 NZ_CP061700:352752-353051 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT172800 NZ_CP079934:5754-6068 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTAAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFK7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References