Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3363706..3364247 Replicon chromosome
Accession NZ_CP061527
Organism Shigella dysenteriae strain HNCMB 20080

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag IC625_RS17980 Protein ID WP_000615980.1
Coordinates 3363969..3364247 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag IC625_RS17975 Protein ID WP_000729709.1
Coordinates 3363706..3363966 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC625_RS17935 3358967..3359661 + 695 WP_087786203.1 IS1-like element IS1N family transposase -
IC625_RS17940 3359675..3359887 + 213 Protein_3506 helix-turn-helix transcriptional regulator -
IC625_RS17950 3360176..3360873 - 698 Protein_3507 IS1 family transposase -
IC625_RS17955 3360928..3361272 - 345 Protein_3508 fimbria/pilus periplasmic chaperone -
IC625_RS17965 3362254..3362571 - 318 Protein_3510 transposase -
IC625_RS17970 3362747..3363496 - 750 WP_011378552.1 C40 family peptidase -
IC625_RS17975 3363706..3363966 + 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IC625_RS17980 3363969..3364247 + 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IC625_RS17985 3364403..3365143 + 741 WP_001225679.1 murein L,D-transpeptidase -
IC625_RS17990 3365114..3365881 - 768 WP_000333379.1 class II glutamine amidotransferase -
IC625_RS17995 3366087..3366665 - 579 WP_005020694.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - fimC / gmhA/lpcA / IlpA 3357918..3408926 51008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T172704 WP_000615980.1 NZ_CP061527:3363969-3364247 [Shigella dysenteriae]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T172704 NZ_CP079884:976798-976950 [Escherichia fergusonii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT172704 WP_000729709.1 NZ_CP061527:3363706-3363966 [Shigella dysenteriae]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT172704 NZ_CP079884:c976756-976704 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References