Detailed information of TA system TA172682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 540533..541212
• Replicon: chromosome
• Accession: NZ_CP061521
• Organism: Acinetobacter baumannii strain CFSAN093707

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FQZ15_RS02740
• Protein ID: WP_000838146.1
• Coordinates: 540533..540715 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FQZ15_RS02745
• Protein ID: WP_000966688.1
• Coordinates: 540808..541212 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQZ15_RS02705	535553..535996	+	444	WP_002016455.1	hypothetical protein	-
FQZ15_RS02710	535998..536216	+	219	WP_001277696.1	hypothetical protein	-
FQZ15_RS02715	536325..536846	+	522	WP_000749909.1	SH3 domain-containing protein	-
FQZ15_RS02720	536943..537296	+	354	WP_000064593.1	hypothetical protein	-
FQZ15_RS02725	537296..538651	+	1356	WP_000002415.1	hypothetical protein	-
FQZ15_RS02730	538704..539621	+	918	WP_000094253.1	hypothetical protein	-
FQZ15_RS02735	539692..540207	+	516	WP_024616020.1	hypothetical protein	-
FQZ15_RS02740	540533..540715	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FQZ15_RS02745	540808..541212	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FQZ15_RS02750	541311..541991	+	681	WP_000721572.1	hypothetical protein	-
FQZ15_RS02755	541993..542256	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	504601..560040	55439

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T172682 WP_000838146.1 NZ_CP061521:540533-540715 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T172682 NZ_CP079862:6705978-6706301 [Frankia sp. ArI3]
CTGTGCCGCACGGACTCCGCCAGTGCGGACCTGGTCGCCGAGGCCATCGACATGCTCGCCGAACACGGGCCCGGCCTGGG
GCGCCCGCTCGTTGACAGACTCACAGGCAGCACCTACCACCACATGAAAGAACTCCGACCGGGCTCGGCCGGGGCCACCG
AGATCCGGCTGATTTTCGCCTTCGACCCACGCCGGGAAGCGGTGTTTCTCGTCGCGGGCGACAAGTCCGGCGTTTGGCGC
ACCTGGTACCAGACCGCAGTCCCGCTCGCAGACGAAAGATTCGGCGAACACTTGAGGATCTTGAAGGAACAGGAGGGATC
ATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT172682 WP_000966688.1 NZ_CP061521:540808-541212 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT172682 NZ_CP079862:6706298-6706630 [Frankia sp. ArI3]
ATGACCACACCGTCGAACTGGCGTGATGTCAAGGCCCGCGCCCGCGCGACCGATCCCAGGTGGGACAGCGCCGCGCGGAC
AGCCCGCCGCGCTGAGATGCGAAGCCAGATGCTCGCCTCCGTCAGCGGCGCGCAACTCGCCGAGATCCGCAATCAACTCG
GCCTCACCCAGGCACAGCTCGCCGAAGCCACCGGCCTGACCCAGGCGAGGATCAGCCAGATCGAGAACGGCACCGCCACG
GGACTGGAGGTTCTGCGCACCTACATCACCGGCCTCGGCGGCCACCTCGACATCGTCGCCCGCATCGGCAACATCCACCT
CAACATCGCCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6