Detailed information of TA system TA172662

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2965331..2966920
• Replicon: chromosome
• Accession: NZ_CP061497
• Organism: Thermomonas sp. XSG

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: ICG51_RS13890
• Protein ID: WP_190280904.1
• Coordinates: 2965331..2966614 (-)
• Length: 428 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: ICG51_RS13895
• Protein ID: WP_190280905.1
• Coordinates: 2966621..2966920 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICG51_RS13865	2960500..2961621	+	1122	WP_190280900.1	glycosyltransferase family 4 protein	-
ICG51_RS13870	2961733..2962185	-	453	WP_190282502.1	fasciclin domain-containing protein	-
ICG51_RS13875	2962659..2963999	+	1341	WP_190280901.1	Na+/H+ antiporter NhaA	-
ICG51_RS13880	2964114..2965124	+	1011	WP_190280902.1	NAD-dependent epimerase	-
ICG51_RS13885	2965142..2965324	+	183	WP_190280903.1	hypothetical protein	-
ICG51_RS13890	2965331..2966614	-	1284	WP_190280904.1	type II toxin-antitoxin system HipA family toxin	Toxin
ICG51_RS13895	2966621..2966920	-	300	WP_190280905.1	helix-turn-helix domain-containing protein	Antitoxin
ICG51_RS13900	2967196..2968875	-	1680	WP_190280906.1	AMP-binding protein	-
ICG51_RS13905	2969016..2969459	+	444	WP_190282503.1	nuclear transport factor 2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (169-400)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-67)

Sequences

Toxin

Protein

• Length: 428 a.a.
• Molecular weight: 47295.65 Da
• Isoelectric Point: 6.9781

>T172662 WP_190280904.1 NZ_CP061497:c2966614-2965331 [Thermomonas sp. XSG]
MKHVDVIEVRIWGKQVGAVAQDPRLGAYVFEYADSWRRTGIALSPFMLPLDRADGRFAFPALDPDAFHRLPGLLADALPD
DFGNQLINGWMASHGIRPEEVTALDRLAYMGRRGMGALEFRPTRGGNTETAAPIEMKALVEVARKAVHGALAGDPEAQAA
LASIIRVGTSAGGARAKAVVAWNPATDELRSGQFDAAPGFEHWLLKFDGMGADQELGQSQCYGRREYAYHLMATAAGITM
SACRLLEENGRAHFMTRRFDRDGNRKIHMQTLAALQHMSHRQRRTHAYESLFITAHGLGLPERDMEQLFLRMAFNVASKN
HDDHTKNFAFLLREGGAWALAPAYDVTHAYNPAGEWTQHHLMSVAGKFDDITADDLREVAARFSIRNPSTLMDQVDAAIA
RWPEFAQVAGLPASDRDDVGRLLIRLR

Nucleotide

• Length: 1284 bp

>T172662 NZ_CP079839:c4160361-4160258 [Salmonella enterica]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10494.17 Da
• Isoelectric Point: 12.2681

>AT172662 WP_190280905.1 NZ_CP061497:c2966920-2966621 [Thermomonas sp. XSG]
MATPSFQTPEEIQTDLGQRLRQLRLGQRLTQAGLATRAGVSPRALRGLESGEGSSLITLIRVLKALGALTSLDALAPQPT
ISPMALLAGNRAPKRGTRH

Nucleotide

• Length: 300 bp

>AT172662 NZ_CP079839:4160256-4160399 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG