Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 385843..386365 Replicon chromosome
Accession NZ_CP061339
Organism Escherichia coli strain M00057

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag IC755_RS01835 Protein ID WP_001105433.1
Coordinates 386075..386365 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WJ36
Locus tag IC755_RS01830 Protein ID WP_000212718.1
Coordinates 385843..386085 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC755_RS01810 381756..383129 + 1374 WP_001219792.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
IC755_RS01815 383212..383763 - 552 WP_000166270.1 ribosome-associated protein -
IC755_RS01820 383857..385209 + 1353 WP_001162171.1 metalloprotease PmbA -
IC755_RS01825 385265..385651 + 387 WP_001232253.1 cytochrome b562 -
IC755_RS01830 385843..386085 + 243 WP_000212718.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IC755_RS01835 386075..386365 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IC755_RS01840 386366..386830 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IC755_RS01845 387010..389148 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
IC755_RS01850 389542..391197 - 1656 WP_001376680.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-66)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T172407 WP_001105433.1 NZ_CP061339:386075-386365 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T172407 NZ_CP079749:35690-35977 [Acinetobacter johnsonii]
ATGGAACAGTATTTCGAATGGGATGAGACAAAGAATCGAAAGAATCAGAAAAAACACGATGTCTCTTTCGAAACGGCAAG
CCTTGTCTTTGAAGATCCATTAAGGATCTCAATCCAGGATAGACATACCGATGGTGAGGAACGTTGGCAAACCATTGGAA
GAGTAAAAGGCGTACTAATGCTATTAGTAGCTCACACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAAGTAACTAAAGCAGAGCGAGATAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9174.63 Da        Isoelectric Point: 5.1369

>AT172407 WP_000212718.1 NZ_CP061339:385843-386085 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLAYPQEAIKVRLDEL

Download         Length: 243 bp

>AT172407 NZ_CP079749:35964-36281 [Acinetobacter johnsonii]
ATGAGCATGGTTAGATACTCACGCAAAGAACTGAATAAAAAATTCAGCGACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAAGGGACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
ATAATCAATTCTATCGCCCAGTGAAGCAACAGACTTCCATCCGTTTAGATGCTGATGTACTTGCATGGTTTAAAGCTCAA
GGCAAAGGCTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTAAAAGAATTAAAAAATCATAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WJ36

References