Detailed information of TA system TA172332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1204893..1205310
• Replicon: chromosome
• Accession: NZ_CP061314
• Organism: Polynucleobacter corsicus strain AP-Melu-1000-A1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: C2747_RS06235
• Protein ID: WP_215330761.1
• Coordinates: 1204893..1205102 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: C2747_RS06240
• Protein ID: WP_215330762.1
• Coordinates: 1205086..1205310 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C2747_RS06215 (C2747_06195)	1200070..1201329	-	1260	WP_215330758.1	efflux RND transporter periplasmic adaptor subunit	-
C2747_RS06220 (C2747_06200)	1201339..1202865	-	1527	WP_251374707.1	TolC family protein	-
C2747_RS06225 (C2747_06205)	1203040..1204458	-	1419	WP_215330759.1	carbohydrate porin	-
C2747_RS06230 (C2747_06210)	1204636..1204833	-	198	WP_285896667.1	hypothetical protein	-
C2747_RS06235 (C2747_06215)	1204893..1205102	-	210	WP_215330761.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C2747_RS06240 (C2747_06220)	1205086..1205310	-	225	WP_215330762.1	DUF6290 family protein	Antitoxin
C2747_RS06245 (C2747_06225)	1205515..1206129	-	615	WP_215330763.1	recombination mediator RecR	-
C2747_RS06250 (C2747_06230)	1206143..1206466	-	324	WP_046330302.1	YbaB/EbfC family nucleoid-associated protein	-
C2747_RS06255 (C2747_06235)	1206494..1208137	-	1644	WP_215330764.1	DNA polymerase III subunit gamma/tau	-
C2747_RS06265 (C2747_06245)	1208598..1209254	+	657	WP_215330765.1	3'-5' exonuclease	-
C2747_RS06270 (C2747_06250)	1209265..1209801	-	537	WP_215330766.1	TIGR00645 family protein	-
C2747_RS10605	1209955..1210086	-	132	WP_285896668.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-66)

Antitoxin

• Protein of unknown function DUF6290 (3-70)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.73 Da
• Isoelectric Point: 10.0994

>T172332 WP_215330761.1 NZ_CP061314:c1205102-1204893 [Polynucleobacter corsicus]
MVWLIEFAPLAEKQLRKFDPKVAKRIFKFCRERLAVQADPRILGEALKGSEYGDYWRYRVGDYRIIAFI

Nucleotide

• Length: 210 bp

>T172332 NZ_CP079735:852075-852482 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8365.80 Da
• Isoelectric Point: 8.4592

>AT172332 WP_215330762.1 NZ_CP061314:c1205310-1205086 [Polynucleobacter corsicus]
MLAIRLPKEIELRLDNLAKATGRTKTFYAREAILAYVEDMEDLYLADKSMRALKSGKVKAIPLDQVERNLGLAD

Nucleotide

• Length: 225 bp

>AT172332 NZ_CP079735:851828-852094 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA