Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5103463..5104264 Replicon chromosome
Accession NZ_CP061206
Organism Escherichia coli strain DA61218

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag ICI53_RS24180 Protein ID WP_000854739.1
Coordinates 5103463..5103843 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag ICI53_RS24185 Protein ID WP_001285482.1
Coordinates 5103890..5104264 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI53_RS24145 5099054..5099608 - 555 WP_001001909.1 molecular chaperone YcdY -
ICI53_RS24150 5099632..5100369 - 738 WP_000283664.1 zinc-binding phosphatase -
ICI53_RS24155 5100424..5101362 - 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
ICI53_RS24165 5101849..5102676 - 828 WP_001304477.1 DUF4942 domain-containing protein -
ICI53_RS24170 5102761..5102958 - 198 WP_000772027.1 DUF957 domain-containing protein -
ICI53_RS24175 5102978..5103466 - 489 WP_001054232.1 hypothetical protein -
ICI53_RS24180 5103463..5103843 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
ICI53_RS24185 5103890..5104264 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ICI53_RS24190 5104314..5104958 - 645 WP_000094915.1 hypothetical protein -
ICI53_RS24195 5104977..5105198 - 222 WP_000692312.1 DUF987 domain-containing protein -
ICI53_RS24200 5105261..5105737 - 477 WP_001186170.1 RadC family protein -
ICI53_RS24205 5105753..5106226 - 474 WP_000855076.1 antirestriction protein -
ICI53_RS24210 5106489..5107310 - 822 WP_001234710.1 DUF945 domain-containing protein -
ICI53_RS24215 5107391..5107602 + 212 Protein_4724 hypothetical protein -
ICI53_RS24220 5107721..5108176 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T172256 WP_000854739.1 NZ_CP061206:c5103843-5103463 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T172256 NZ_CP079685:c44092-43676 [Klebsiella pneumoniae subsp. pneumoniae]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT172256 WP_001285482.1 NZ_CP061206:c5104264-5103890 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT172256 NZ_CP079685:c44319-44089 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References