Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3997955..3998781 Replicon chromosome
Accession NZ_CP061206
Organism Escherichia coli strain DA61218

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag ICI53_RS18615 Protein ID WP_001620456.1
Coordinates 3997955..3998329 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag ICI53_RS18620 Protein ID WP_024186744.1
Coordinates 3998419..3998781 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI53_RS18575 3993351..3994517 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
ICI53_RS18580 3994636..3995109 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
ICI53_RS18585 3995307..3996365 + 1059 WP_001200890.1 FUSC family protein -
ICI53_RS18590 3996537..3996866 + 330 WP_000450409.1 DUF496 family protein -
ICI53_RS18595 3996967..3997149 - 183 WP_001016348.1 hypothetical protein -
ICI53_RS18600 3997203..3997349 + 147 Protein_3619 transposase domain-containing protein -
ICI53_RS18605 3997638..3997751 - 114 WP_001161660.1 DUF957 domain-containing protein -
ICI53_RS18610 3997764..3997958 - 195 WP_000988601.1 hypothetical protein -
ICI53_RS18615 3997955..3998329 - 375 WP_001620456.1 TA system toxin CbtA family protein Toxin
ICI53_RS18620 3998419..3998781 - 363 WP_024186744.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ICI53_RS18625 3998860..3999081 - 222 WP_000692312.1 DUF987 domain-containing protein -
ICI53_RS18630 3999150..3999626 - 477 WP_001186708.1 RadC family protein -
ICI53_RS18635 3999642..4000127 - 486 WP_000206667.1 antirestriction protein -
ICI53_RS18640 4000219..4001040 - 822 WP_001620455.1 DUF945 domain-containing protein -
ICI53_RS18645 4001261..4001671 - 411 WP_000846704.1 hypothetical protein -
ICI53_RS18650 4001687..4002364 - 678 WP_001362823.1 hypothetical protein -
ICI53_RS18655 4002500..4003570 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(16-115)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14077.11 Da        Isoelectric Point: 7.7761

>T172245 WP_001620456.1 NZ_CP061206:c3998329-3997955 [Escherichia coli]
MKTLPDTHIREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTQFADERVIELHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T172245 NZ_CP079673:4706505-4707827 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13354.17 Da        Isoelectric Point: 6.6247

>AT172245 WP_024186744.1 NZ_CP061206:c3998781-3998419 [Escherichia coli]
VSDTLPGTTHPDNNRPWWGLPCTVMPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSGEL
NPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTSETKK

Download         Length: 363 bp

>AT172245 NZ_CP079673:4706239-4706505 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References