Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2940588..2941422 Replicon chromosome
Accession NZ_CP061206
Organism Escherichia coli strain DA61218

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag ICI53_RS13805 Protein ID WP_000854690.1
Coordinates 2940588..2940965 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag ICI53_RS13810 Protein ID WP_001305076.1
Coordinates 2941054..2941422 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI53_RS13775 2936982..2937137 - 156 WP_000729638.1 hypothetical protein -
ICI53_RS13780 2937569..2938502 - 934 Protein_2680 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
ICI53_RS13785 2938495..2938890 - 396 WP_000208382.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
ICI53_RS13790 2938959..2939804 - 846 WP_001529401.1 DUF4942 domain-containing protein -
ICI53_RS13795 2939889..2940086 - 198 WP_000839293.1 DUF957 domain-containing protein -
ICI53_RS13800 2940103..2940591 - 489 WP_000761699.1 hypothetical protein -
ICI53_RS13805 2940588..2940965 - 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
ICI53_RS13810 2941054..2941422 - 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ICI53_RS13815 2941472..2942116 - 645 WP_000094916.1 hypothetical protein -
ICI53_RS13820 2942135..2942356 - 222 WP_000692329.1 DUF987 domain-containing protein -
ICI53_RS13825 2942419..2942895 - 477 WP_001186726.1 RadC family protein -
ICI53_RS13830 2942911..2943396 - 486 WP_000849565.1 antirestriction protein -
ICI53_RS13835 2943451..2944269 - 819 WP_001234620.1 DUF945 domain-containing protein -
ICI53_RS13840 2944370..2944603 - 234 WP_000902034.1 DUF905 family protein -
ICI53_RS13845 2944682..2945137 - 456 WP_000581502.1 hypothetical protein -
ICI53_RS13850 2945213..2946340 - 1128 Protein_2694 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - ugd / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / sat 2921038..2987103 66065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T172241 WP_000854690.1 NZ_CP061206:c2940965-2940588 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T172241 NZ_CP079673:2663799-2664083 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT172241 WP_001305076.1 NZ_CP061206:c2941422-2941054 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT172241 NZ_CP079673:2663567-2663809 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PLF5


Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References