Detailed information of TA system TA172040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 596196..596761
• Replicon: chromosome
• Accession: NZ_CP061081
• Organism: Marinomonas arctica strain BSI20414

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IBG28_RS02735
• Protein ID: WP_111608545.1
• Coordinates: 596196..596483 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IBG28_RS02740
• Protein ID: WP_162623547.1
• Coordinates: 596480..596761 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBG28_RS02710	591607..592728	-	1122	WP_111608540.1	TOBE-like domain-containing protein	-
IBG28_RS02715	592725..593606	-	882	WP_111608541.1	sulfate ABC transporter permease subunit CysW	-
IBG28_RS02720	593616..594476	-	861	WP_111608542.1	sulfate/thiosulfate ABC transporter permease CysT	-
IBG28_RS02725	594583..595596	-	1014	WP_111608543.1	thiosulfate ABC transporter substrate-binding protein CysP	-
IBG28_RS02730	595711..596022	-	312	WP_111608544.1	cupin domain-containing protein	-
IBG28_RS02735	596196..596483	-	288	WP_111608545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IBG28_RS02740	596480..596761	-	282	WP_162623547.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IBG28_RS02745	596939..597169	+	231	WP_111608547.1	helix-turn-helix domain-containing protein	-
IBG28_RS02750	597166..598590	+	1425	WP_111608548.1	chorismate-binding protein	-
IBG28_RS02755	598602..599264	+	663	WP_111608549.1	aminodeoxychorismate/anthranilate synthase component II	-
IBG28_RS02760	599438..599971	+	534	WP_111608550.1	DUF2442 domain-containing protein	-
IBG28_RS02765	600113..600415	+	303	WP_111608551.1	helix-turn-helix transcriptional regulator	-
IBG28_RS02770	601041..601244	+	204	WP_188323018.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-73)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10964.69 Da
• Isoelectric Point: 5.8348

>T172040 WP_111608545.1 NZ_CP061081:c596483-596196 [Marinomonas arctica]
MKVSWSPLAMEKLGHAADFIALDNPNAAEKWVNDLFDKTDLLSRQPEMGRIVPELQKANLRELIFGNYRVIYTISTEIRI
LTVRNCRQMLTESDL

Nucleotide

• Length: 288 bp

>T172040 NZ_CP079164:2663799-2664083 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10604.20 Da
• Isoelectric Point: 6.3737

>AT172040 WP_162623547.1 NZ_CP061081:c596761-596480 [Marinomonas arctica]
MSRINLDQDIQPLSEFRSGVTSFIKQINETRRPLLITQRGKGVAVMLDVAEYEAMQEKIELLEEIRTAESQFAEGLGISN
QEARKQILGRLKK

Nucleotide

• Length: 282 bp

>AT172040 NZ_CP079164:2663567-2663809 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA