Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 121075..121308 | Replicon | plasmid pEC5-2 |
| Accession | NZ_CP060970 | ||
| Organism | Escherichia coli strain EC5 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | H9193_RS23940 | Protein ID | WP_001372321.1 |
| Coordinates | 121075..121200 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 121277..121308 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9193_RS23900 (116449) | 116449..117138 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| H9193_RS23905 (117325) | 117325..117708 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| H9193_RS23910 (118029) | 118029..118631 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| H9193_RS23915 (118928) | 118928..119749 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| H9193_RS23920 (119867) | 119867..120154 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| H9193_RS23925 (120179) | 120179..120385 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| H9193_RS23930 (120455) | 120455..120627 | + | 173 | Protein_134 | hypothetical protein | - |
| H9193_RS23935 (120625) | 120625..120855 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| H9193_RS23940 (121075) | 121075..121200 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| H9193_RS23945 (121142) | 121142..121291 | - | 150 | Protein_137 | plasmid maintenance protein Mok | - |
| - (121277) | 121277..121308 | - | 32 | NuclAT_1 | - | Antitoxin |
| - (121277) | 121277..121308 | - | 32 | NuclAT_1 | - | Antitoxin |
| - (121277) | 121277..121308 | - | 32 | NuclAT_1 | - | Antitoxin |
| - (121277) | 121277..121308 | - | 32 | NuclAT_1 | - | Antitoxin |
| - (122750) | 122750..122947 | - | 198 | NuclAT_0 | - | - |
| - (122750) | 122750..122947 | - | 198 | NuclAT_0 | - | - |
| - (122750) | 122750..122947 | - | 198 | NuclAT_0 | - | - |
| - (122750) | 122750..122947 | - | 198 | NuclAT_0 | - | - |
| H9193_RS23955 (122759) | 122759..122947 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| H9193_RS23960 (122916) | 122916..123678 | - | 763 | Protein_140 | plasmid SOS inhibition protein A | - |
| H9193_RS23965 (123675) | 123675..124109 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| H9193_RS23970 (124164) | 124164..124361 | - | 198 | Protein_142 | hypothetical protein | - |
| H9193_RS23975 (124389) | 124389..124622 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| H9193_RS23980 (124690) | 124690..125229 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| H9193_RS23985 (125255) | 125255..125461 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| H9193_RS23990 (125531) | 125531..125611 | + | 81 | Protein_146 | hypothetical protein | - |
| H9193_RS23995 (125794) | 125794..125963 | - | 170 | Protein_147 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-14 / fosA3 / aac(3)-IVa / sul2 / floR / dfrA12 / aadA2 / qacE / mph(A) / aph(3')-Ia / blaTEM-1B / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..147909 | 147909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T171808 WP_001372321.1 NZ_CP060970:c121200-121075 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T171808 NZ_CP078122:878047-878454 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
Antitoxin
Download Length: 32 bp
>AT171808 NZ_CP060970:c121308-121277 [Escherichia coli]
CACCACGAGGCATCCCTATGTCTAGTCCACAT
CACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
