Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 712652..713345 Replicon chromosome
Accession NZ_CP060963
Organism Escherichia coli strain EC7

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9194_RS03470 Protein ID WP_000415584.1
Coordinates 712652..712948 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9194_RS03475 Protein ID WP_000650107.1
Coordinates 712950..713345 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9194_RS03435 (707752) 707752..708066 - 315 WP_000958598.1 putative quinol monooxygenase -
H9194_RS03440 (708097) 708097..708678 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9194_RS03445 (708997) 708997..709329 + 333 WP_000917684.1 DUF2645 family protein -
H9194_RS03450 (709375) 709375..710724 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
H9194_RS03455 (710721) 710721..711380 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9194_RS03460 (711532) 711532..711924 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9194_RS03465 (711977) 711977..712447 + 471 WP_241462804.1 GyrI-like domain-containing protein -
H9194_RS03470 (712652) 712652..712948 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9194_RS03475 (712950) 712950..713345 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9194_RS03480 (713478) 713478..715085 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9194_RS03485 (715223) 715223..717481 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171747 WP_000415584.1 NZ_CP060963:712652-712948 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171747 NZ_CP078091:185284-186555 [Porphyrobacter sp. ULC335]
ATGACGCCGCCGATCCTCGATACTCTCAGGGTCTGGTGGGACCGGCGCCAGGCAGGCGAGCTTGCTATCGACAAGGGCGG
CGCAATGCATTTCGCCTATTCGGCTGAATGGCTGGCGGATGACAGCGCACCCCCACTTTCGCAGGCCCTGCCCAAGCGAG
GCGAAGCCTTTGACGATCACGTATGCAAGGCAGTCTTCGGAGGCCTCCTGCCTGAAGAGAGCCAGCGGACGGCGATAGCG
CGCGCGCTCGGCGTGTCGCCGGACAATCCATTCCGCCTGCTTCAGGCTCTTGGCGGCGATGTGGCGGGAGCACTTTCGTT
CCTGCCTGCGGGCGAGGAGCCCCTCCAGGACGAAACCAATGGTGATGCCGAGCCGCTCGATGAGGGGGAGCTGGCGGCCC
TGCTCGACCGCCTCCCGGCGGCGCCCATGCTTGCCGGTGAAGGCGGGCCACGGCTGAGTCTGGCCGGTGCACAAAGCAAG
CTCCCGGTGGTCCTGACAGCAAATGGCCGGATCGCGGTCCCGCGCCCGGGTGAACCTTCGACACACCTCATCAAGCCGGA
GCCGGAGCGATTTGCCGGCCTTGCAGCGAATGAAGCCTTCTGTCTTGCTCTGGCCAGCGCGGTAGGTCTCGATACAGCCA
GAGCCGAATGGCGGGAGGTAGACGGCAGGCCGCTGCTTCTCGTCGAAAGATACGACCGCGTATCGGTCGGAGGCAGGACG
CAGCGCCTGCATCAGGAGGACTTCGCGCAGGCACTGGCGGTGCCTTCGAACAGGAAATACGCAGCCGAAGGCGGTCCGAC
ATTCCTCGACAGTTTTGCGCTCCTGCGGAGCGCTGCGACGCGCCCGGCACGCGAAGTGCTGAAGCTCGCCGATGCGGCCA
TTTTCAATCTCATTGTCGGAAATGCCGATGCCCACGCCAAGAACTACAGCTTGCTGCGCCTGCAGACGGGTGAGGTCGTT
CTTGCACCGCTCTACGATCATGTGGCCACCCATATGTGGAAAGAGCTGTCGCCCAGTCTGGCGATGCGATTTGGCCGGGC
GGCCACGATAGAGGAACTCGGGAAGGACAATCTGGAACGATTTGCTGAGGATGCGGGGCTGCCCGCTCCTTTCGTGAAGC
GAAGACTGTTCCAGATCGCGGTAGCCCTGAGCAGGGAGATCGCAAAAGGAGTGTTCGTGCGCGGTCTCGACGACCAGAAT
GCCATCGCACCAGTGGCAGAGGCGGTCGCGATGAGGGCAGCATACGCTCGCGATGGGCACCCGAGCACGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171747 WP_000650107.1 NZ_CP060963:712950-713345 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171747 NZ_CP078091:185030-185287 [Porphyrobacter sp. ULC335]
GTGCTCACTGTCACCACCATTGGCGCCATCATTCGCGACGAGCGCAAGGCGCTCGGCCTGCGGCAGGACGAGCTCGCGGC
AGCGAGCGGCGTGGGCCTGCGGTTTCTGGTCGAGCTGGAGCGGGGCAAGCCCACCGTGCAGATGGGCAAGGTTCTCGATG
TCCTCGCTGCCCTCGGATGCGATTTGCAAATCCTCGGCCCTGCCGGCGATGCCATTGTTCCGCAACCACCGGCATCTGTC
AGGAGTTCAGGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References