Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1876330..1877162 Replicon chromosome
Accession NZ_CP060873
Organism Escherichia coli strain EC27

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag H9210_RS08950 Protein ID WP_001514886.1
Coordinates 1876330..1876704 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag H9210_RS08955 Protein ID WP_001360327.1
Coordinates 1876794..1877162 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9210_RS08915 (1871846) 1871846..1872319 + 474 WP_001105385.1 DNA gyrase inhibitor SbmC -
H9210_RS08920 (1872518) 1872518..1873576 + 1059 WP_032181141.1 FUSC family protein -
H9210_RS08925 (1873748) 1873748..1874077 + 330 WP_000450409.1 DUF496 family protein -
H9210_RS08930 (1874178) 1874178..1874444 - 267 WP_063121129.1 EutP/PduV family microcompartment system protein -
H9210_RS08935 (1874814) 1874814..1875185 - 372 WP_001295631.1 IS110 family transposase -
H9210_RS08940 (1876001) 1876001..1876081 - 81 Protein_1757 hypothetical protein -
H9210_RS08945 (1876181) 1876181..1876333 - 153 Protein_1758 DUF5983 family protein -
H9210_RS08950 (1876330) 1876330..1876704 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
H9210_RS08955 (1876794) 1876794..1877162 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H9210_RS08960 (1877325) 1877325..1877546 - 222 WP_000692286.1 DUF987 domain-containing protein -
H9210_RS08965 (1877609) 1877609..1878085 - 477 WP_001186774.1 RadC family protein -
H9210_RS08970 (1878101) 1878101..1878574 - 474 WP_000855059.1 antirestriction protein -
H9210_RS08975 (1878916) 1878916..1879734 - 819 WP_088540043.1 DUF932 domain-containing protein -
H9210_RS08980 (1879852) 1879852..1880047 - 196 Protein_1765 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T171265 WP_001514886.1 NZ_CP060873:c1876704-1876330 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T171265 NZ_CP077869:c2190815-2190549 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT171265 WP_001360327.1 NZ_CP060873:c1877162-1876794 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT171265 NZ_CP077869:c2191066-2190815 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References