Detailed information of TA system TA171208

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3533096..3533488
• Replicon: chromosome
• Accession: NZ_CP060855
• Organism: Salmonella enterica strain 453

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: IAQ58_RS17130
• Protein ID: WP_000994223.1
• Coordinates: 3533243..3533488 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3533096..3533452 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAQ58_RS17100	3528348..3528845	-	498	WP_165963407.1	pilus assembly protein	-
IAQ58_RS17105	3529607..3530311	-	705	Protein_3348	integrase core domain-containing protein	-
IAQ58_RS17110	3530364..3530678	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
IAQ58_RS17115	3530745..3531023	-	279	WP_133323248.1	hypothetical protein	-
IAQ58_RS17120	3531341..3531808	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
IAQ58_RS17125	3532626..3533045	-	420	WP_131040133.1	hypothetical protein	-
-	3533096..3533452	-	357	-	-	Antitoxin
IAQ58_RS17130	3533243..3533488	+	246	WP_000994223.1	hypothetical protein	Toxin
IAQ58_RS17135	3533555..3534097	-	543	WP_079984650.1	hypothetical protein	-
IAQ58_RS17140	3534097..3538203	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3523265..3534097	10832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T171208 WP_000994223.1 NZ_CP060855:3533243-3533488 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T171208 NZ_CP077860:c1117549-1117445 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT171208 NZ_CP060855:c3533452-3533096 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin