Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4522249..4523003 Replicon chromosome
Accession NZ_CP060852
Organism Salmonella enterica strain 467

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAR30_RS21655 Protein ID WP_133323219.1
Coordinates 4522249..4522560 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAR30_RS21660 Protein ID WP_001259009.1
Coordinates 4522557..4523003 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR30_RS21625 (4517907) 4517907..4518809 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
IAR30_RS21630 (4518806) 4518806..4519441 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
IAR30_RS21635 (4519438) 4519438..4520367 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IAR30_RS21640 (4520414) 4520414..4520704 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
IAR30_RS21645 (4520705) 4520705..4521016 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
IAR30_RS21650 (4521234) 4521234..4522163 + 930 WP_001127694.1 alpha/beta hydrolase -
IAR30_RS21655 (4522249) 4522249..4522560 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
IAR30_RS21660 (4522557) 4522557..4523003 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
IAR30_RS21665 (4523018) 4523018..4523959 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IAR30_RS21670 (4524004) 4524004..4524441 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
IAR30_RS21675 (4524438) 4524438..4525310 - 873 WP_000921423.1 virulence factor BrkB family protein -
IAR30_RS21680 (4525304) 4525304..4525903 - 600 WP_000965698.1 glucose-1-phosphatase -
IAR30_RS21685 (4526094) 4526094..4526897 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
IAR30_RS21690 (4526931) 4526931..4527827 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T171194 WP_133323219.1 NZ_CP060852:4522249-4522560 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T171194 NZ_CP077859:2202616-2202723 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT171194 WP_001259009.1 NZ_CP060852:4522557-4523003 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT171194 NZ_CP077859:c2202800-2202740 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References