Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3372233..3372853 Replicon chromosome
Accession NZ_CP060852
Organism Salmonella enterica strain 467

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IAR30_RS16335 Protein ID WP_001280991.1
Coordinates 3372635..3372853 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IAR30_RS16330 Protein ID WP_000344807.1
Coordinates 3372233..3372607 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR30_RS16320 (3367372) 3367372..3368565 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IAR30_RS16325 (3368588) 3368588..3371737 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
IAR30_RS16330 (3372233) 3372233..3372607 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IAR30_RS16335 (3372635) 3372635..3372853 + 219 WP_001280991.1 HHA domain-containing protein Toxin
IAR30_RS16340 (3373032) 3373032..3373583 + 552 WP_001278793.1 maltose O-acetyltransferase -
IAR30_RS16345 (3373699) 3373699..3373857 + 159 Protein_3198 YlaC family protein -
IAR30_RS16350 (3374090) 3374090..3375625 + 1536 WP_000447015.1 IS21 family transposase -
IAR30_RS16355 (3375642) 3375642..3376397 + 756 WP_032163908.1 IS21-like element ISSso4 family helper ATPase IstB -
IAR30_RS16360 (3376494) 3376494..3376814 + 321 Protein_3201 YlaC family protein -
IAR30_RS16365 (3376870) 3376870..3377010 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IAR30_RS16370 (3377016) 3377016..3377276 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T171188 WP_001280991.1 NZ_CP060852:3372635-3372853 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T171188 NZ_CP077858:2584797-2585159 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT171188 WP_000344807.1 NZ_CP060852:3372233-3372607 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT171188 NZ_CP077858:2584630-2584800 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References