Detailed information of TA system TA171179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1038924..1039738
• Replicon: chromosome
• Accession: NZ_CP060852
• Organism: Salmonella enterica strain 467

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: IAR30_RS04930
• Protein ID: WP_000971651.1
• Coordinates: 1038924..1039451 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: IAR30_RS04935
• Protein ID: WP_000855694.1
• Coordinates: 1039448..1039738 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR30_RS04900 (1035198)	1035198..1035596	+	399	Protein_963	cytoplasmic protein	-
IAR30_RS04905 (1035787)	1035787..1036026	+	240	Protein_964	hypothetical protein	-
IAR30_RS04910 (1036183)	1036183..1036851	+	669	WP_000445914.1	hypothetical protein	-
IAR30_RS04915 (1036878)	1036878..1037372	+	495	WP_020899151.1	hypothetical protein	-
IAR30_RS04920 (1037544)	1037544..1038200	-	657	WP_023181885.1	protein-serine/threonine phosphatase	-
IAR30_RS04925 (1038433)	1038433..1038851	+	419	Protein_968	transposase	-
IAR30_RS04930 (1038924)	1038924..1039451	-	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
IAR30_RS04935 (1039448)	1039448..1039738	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
IAR30_RS04940 (1040332)	1040332..1040658	+	327	WP_000393295.1	hypothetical protein	-
IAR30_RS04945 (1040931)	1040931..1041278	-	348	WP_001555786.1	DUF1493 family protein	-
IAR30_RS04950 (1041263)	1041263..1041712	-	450	WP_133322517.1	hypothetical protein	-
IAR30_RS04955 (1042144)	1042144..1042587	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
IAR30_RS04960 (1043044)	1043044..1043694	+	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1037544..1049007	11463
	-	flank	IS/Tn	-	-	1038675..1038851	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T171179 WP_000971651.1 NZ_CP060852:c1039451-1038924 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T171179 NZ_CP077857:2678722-2678898 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT171179 WP_000855694.1 NZ_CP060852:c1039738-1039448 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT171179 NZ_CP077857:c2679060-2678886 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7