Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 327199..327859 Replicon chromosome
Accession NZ_CP060849
Organism Salmonella enterica strain 724

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag IAR31_RS01625 Protein ID WP_000244757.1
Coordinates 327199..327612 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag IAR31_RS01630 Protein ID WP_000351186.1
Coordinates 327593..327859 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR31_RS01605 (323140) 323140..324873 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
IAR31_RS01610 (324879) 324879..325592 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IAR31_RS01615 (325616) 325616..326512 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
IAR31_RS01620 (326625) 326625..327146 + 522 WP_001055885.1 flavodoxin FldB -
IAR31_RS01625 (327199) 327199..327612 - 414 WP_000244757.1 protein YgfX Toxin
IAR31_RS01630 (327593) 327593..327859 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
IAR31_RS01635 (328109) 328109..329089 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
IAR31_RS01640 (329205) 329205..329864 - 660 WP_000250289.1 hemolysin III family protein -
IAR31_RS01645 (330028) 330028..330339 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
IAR31_RS01650 (330498) 330498..331931 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T171158 WP_000244757.1 NZ_CP060849:c327612-327199 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T171158 NZ_CP077856:4205-4357 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT171158 WP_000351186.1 NZ_CP060849:c327859-327593 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT171158 NZ_CP077856:3581-4180 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References